Preparation of Copper-Carbon Dots Complex and Its Antibacterial Activity
Pseudomonas aeruginosa(P.aeruginosa)is a major pathogen of hospital-acquired infections and has high drug resistance,so it is urgent to develop new strategies and efficient drug molecules to deal with this problem.In this paper,blue fluorescent carbon dots(CDs)with high antibacterial activity was synthesized by hydrothermal method using citric acid and(2-methyl-5-nitrophenyl)guanidine nitrate as raw materials.The morphology of CDs shows that they are the uniformly dispersed nanospheres with a particle size of about 3 nm.The composition and optical properties show that there are functional groups such as carboxyl and amino groups on the surface of CDs,and the CDs can generate reactive oxygen species under light stimulation.In order to improve antibacterial ac-tivity and the ability to promote wound healing,the CDs further chelated Cu2+to obtain composite CDs@Cu.The killing rate of CDs on P.aeruginosa under xenon lamp irradiation is 85.4%when the concentration was 30 µg/mL,and the killing efficiency of CDs@Cu can reach to 99.9%.Therefore,the composite nanoparticles can not only be used as a new and efficient antibacterial mate-rial,but also provided new ideas and methods for the development of antibacterial agents based on carbon dots.
Pseudomonas aeruginosareactive oxygen speciescopper ionguanidine group
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