磁性介孔纳米材料的制备及性能的研究
Preparation and properties of magnetic mesoporous nanomaterials
贾承政 1李婷婷 1胡云霞 1郭嘉暄1
作者信息
- 1. 上海理工大学 材料与化学学院,上海 200093
- 折叠
摘要
通过水热法合成了分散性良好的Fe3O4 纳米微球,在其外层包覆了介孔二氧化硅(MSN),并进一步修饰了壳聚糖(CS)和透明质酸(HA),形成了高分散的纳米微球Fe3O4@SiO2@MSN@CS@HA.通过扫描电镜(SEM)、透射电镜(TEM)表征了纳米微球的结构、形貌、粒径及分散性.利用热重分析仪(TGA)和比表面分析仪(BET)测试了其外层含量、比表面积和孔径大小.通过紫外可见光谱分析仪测定了参与芬顿反应的性能,并计算其反应速率.结果表明,纳米微球具有良好的分散性和载药能力,且含有的二价铁离子(Fe2+)可以进一步实现肿瘤的化学动力学治疗潜力.
Abstract
Fe3O4 Nanospheres with good dispersibility were synthesized by hydrothermal method,and me-soporous silica(MSN)was coated on their outer layer.Chitosan(CS)and hyaluronic acid(HA)were further modified to form highly dispersed nanospheres Fe3O4@SiO2@MSN@CS@HA.The structure,morphology,particle size,and dispersibility of several nanospheres were characterized by scanning electron microscopy(SEM)and transmission electron microscopy(TEM).The outer layer content,specific sur-face area,and pore size were measured using a thermogravimetric analyzer(TGA)and a specific surface area analyzer(BET).The performance of the Fenton reaction was measured using a UV visible spectros-copy analyzer and its reaction rate was calculated.The results indicate that nanospheres have good disper-sibility and drug loading ability,and the divalent iron ions(Fe2+)they contain can further realize the po-tential of chemodynamic therapy(CDT)for tumors.
关键词
介孔纳米材料/芬顿反应/化学动力学治疗Key words
mesoporous nanomaterials/Fenton reaction/chemodynamic therapy引用本文复制引用
基金项目
国家自然科学基金(81972904)
上海市大学生创新创业训练计划(SH2023230)
上海理工大学材料与化学学院重点攻关课题(十四五)(SSWGGKT004)
出版年
2024
NETL
NSTL
万方数据