Fe3O4磁性纳米颗粒的修饰及在肿瘤治疗中的应用
Modification of Fe3O4 magnetic nanoparticles and its application in tumor therapy
刘锦博 1王倩男 1张静1
作者信息
- 1. 郑州大学 化工学院,河南 郑州 450001
- 折叠
摘要
综述了对四氧化三铁磁性纳米颗粒(Fe3O4-MNPs)的功能化修饰以及其在肿瘤治疗中的应用.重点阐述了无机纳米粒子和有机聚合物对Fe3O4-MNPs的修饰,以提升磁性纳米材料的稳定性、分散性及生物相容性;以及Fe3O4-MNPs在治疗中作为药物载体、磁热疗、磁共振成像、光动力疗法以及多功能肿瘤治疗体系的应用等.讨论了Fe3O4-MNPs在应用过程中可能存在的问题并对未来的发展进行了展望.Fe3O4-MNPs的大小、形状和剂量将会是评估的首要指标,在治疗应用过程中的细胞毒性问题或将成为关键难题.通过寻求新的修饰材料,合成多功能、成本低以及应用方便地Fe3O4-MNPs是今后主要的研究热点.
Abstract
The functionalized Fe3O4-MNPs and their application in tumor therapy are reviewed.The modi-fication of Fe3O4-MNPs by inorganic nanoparticles and organic polymers in order to enhance the stability,dispersibility and biocompatibility of magnetic nanomaterials is highlighted.And the application of Fe3O4-MNPs in treatment as drug carrier,magnetic hyperthermia,magnetic resonance imaging,photodynamic therapy.The possible problems in the application of Fe3O4-MNPs are discussed and the future develop-ment is prospected.It is pointed out that the size,shape and dose of Fe3O4-MNPs will be the primary indi-cators of evaluation,and the cytotoxicity problems in therapeutic applications may become a key chal-lenge.The synthesis of multifunctional,low cost and convenient application of Fe3O4-MNPs by seeking new modified materials is the main research focus in the future.
关键词
四氧化三铁/磁性/纳米颗粒/修饰/肿瘤治疗Key words
ferric oxide/magnetic/nanoparticles/modified/tumor therapy引用本文复制引用
出版年
2024
NETL
NSTL
万方数据