Modification of Fe3O4 magnetic nanoparticles and its application in tumor therapy
The functionalized Fe3O4-MNPs and their application in tumor therapy are reviewed.The modi-fication of Fe3O4-MNPs by inorganic nanoparticles and organic polymers in order to enhance the stability,dispersibility and biocompatibility of magnetic nanomaterials is highlighted.And the application of Fe3O4-MNPs in treatment as drug carrier,magnetic hyperthermia,magnetic resonance imaging,photodynamic therapy.The possible problems in the application of Fe3O4-MNPs are discussed and the future develop-ment is prospected.It is pointed out that the size,shape and dose of Fe3O4-MNPs will be the primary indi-cators of evaluation,and the cytotoxicity problems in therapeutic applications may become a key chal-lenge.The synthesis of multifunctional,low cost and convenient application of Fe3O4-MNPs by seeking new modified materials is the main research focus in the future.
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