The synthesis methods of isothiazolinone compounds,the modification methods of each site and the application progress in the fields of industry,agriculture and medicine are reviewed.The kind of com-pound has a wide range of biological activities,such as high efficiency,low toxicity and broad spectrum.It is mainly used in sterilization,algae killing,anticorrosion,antifouling and so on.It is a hot spot in the field of chemical research in recent years.At present,there are commercial products such as Kathon and Sea-Nine 211(DCOIT).Isothiazolinone compounds play an important role in industrial and agricultural pro-duction and life.The application and research progress of isothiazolinone and its derivatives in medicine,pesticide,coating,textile,papermaking,leather making and other fields in recent years were discussed.Fi-nally,the development direction and application prospect of isothiazolinone compounds were prospected.