Review on synthesis and biological activity of isothiazolinone and its derivatives
The synthesis methods of isothiazolinone compounds,the modification methods of each site and the application progress in the fields of industry,agriculture and medicine are reviewed.The kind of com-pound has a wide range of biological activities,such as high efficiency,low toxicity and broad spectrum.It is mainly used in sterilization,algae killing,anticorrosion,antifouling and so on.It is a hot spot in the field of chemical research in recent years.At present,there are commercial products such as Kathon and Sea-Nine 211(DCOIT).Isothiazolinone compounds play an important role in industrial and agricultural pro-duction and life.The application and research progress of isothiazolinone and its derivatives in medicine,pesticide,coating,textile,papermaking,leather making and other fields in recent years were discussed.Fi-nally,the development direction and application prospect of isothiazolinone compounds were prospected.