首页|聚焦超声在多模式协同治疗肝癌方面的最新研究进展

聚焦超声在多模式协同治疗肝癌方面的最新研究进展

The latest research progress of focused ultrasound in multi-modal synergistic treatment of liver cancer

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声动力疗法(Sonodynamic Therapy,SDT)是一种利用聚焦超声非入侵性治疗癌症的手段,基于SDT的协同策略治疗肝癌,具有较高的研究意义和临床转化价值.总结了 SDT的治疗机理和常见声敏剂,分析了基于单模态声动力疗法很难满足现阶段治疗肝癌肿瘤原因,重点阐述声动力疗法和化疗、光动力治疗、光热治疗等双重协同治疗模式以及基于声动力的多模式协同治疗的研究进展,旨在为今后SDT协同模式治疗肝癌及其它类型癌症提供参考和借鉴,同时提出SDT协同治疗在研究过程中仍面临的单一治疗效果不显著和多模态联合治疗研究较少等问题,最后提出了开发新型声敏剂、探究联合治疗机理以及实现实时诊疗等应用等发展前景.
Sonodynamic Therapy(SDT)is a non-invasive means of cancer treatment using focused ultra-sound.The synergistic strategy based on SDT for liver cancer has high research significance and clinical translational value.This paper summarized the therapeutic mechanism and common acoustic sensitivities of SDT,analyzed the reasons why it is difficult to satisfy the current treatment of liver cancer tumors based on single mode acoustic dynamic therapy,and focused on the research progress of acoustic dynamic thera-py,chemotherapy,photodynamic therapy,photothermal therapy and other dual synergistic treatment modes,as well as multi-mode synergistic therapy based on acoustic dynamic therapy.The aim is to provide reference and guidance for the future SDT collaborative mode treatment of liver cancer and other types of cancer.At the same time,it points out that SDT collaborative therapy still faces problems in the research process,such as the insignificant effect of single therapy and the few studies on multi-modal combined therapy.Finally,it puts forward the development prospect of developing new acoustic sensitizing agents,exploring the mechanism of combined therapy and realizing real-time diagnosis and treatment.

sonodynamic therapysonosensitizerstumor microenvironmentsynergistic treatmentliver cancer

孙勇艳、何俊男、赵焱、晏瑾、张金、杨建梅

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云南师范大学化学化工学院,云南昆明 650500

声动力治疗 声敏剂 肿瘤微环境 协同治疗 肝癌

国家自然科学基金地区项目云南省科技厅基础研究青年项目云南师范大学博士科研启动项目云南省基础研究专项-青年项目云南省基础研究专项面上项目

219610462019FD11501100205020503205202201AU070056202301AT070074

2024

应用化工
陕西省石油化工研究设计院　陕西省化工学会

应用化工

CSTPCD北大核心
影响因子：0.411
ISSN：1671-3206
年,卷(期)：2024.53(7)