The formation mechanism of antibiotics resistance genes(ARGs)in the environment was de-scribed from the perspective of DNA damage and error repair,and the relevant core functional gene frag-ments involved in DNA damage and error repair were summarized.Three main mechanisms of horizontal transfer of ARGs in the environment,including pili bridging,signal transduction and type Ⅳ cell secretion system were discussed from the perspective of cell metabolism.The existing studies further strengthen the understanding of the formation and transfer mechanism of ARGs in the environment,and provide a theoret-ical basis for future research on the reduction of ARGs.At present,the internal mechanism of antibiotic induced ARGs formation and transfer was still relatively lacking,and further studies could be conducted from the biological toxicity and molecular biology levels.
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