Enrichment of total flavonoids from Cistanche deserticola by MOF materials
The performance of different MOFs in the enrichment and separation of total flavonoids from Cistanche deserticola Y.C.Ma and the optimal adsorption and resolution conditions was investigated.Five MOFs,[Zn(nicotinate)2]n,MIL-101(Cr),MIL-101(Fe),MIL-53(Fe)and MOF-5,were synthesized by hydrothermal synthesis,and characterized by PXRD,FTIR,SEM and TG to ensure the accurate synthesis,and the adsorption and desorption quantities under different conditions were taken as the indexes for eval-uating adsorption and desorption performance.After screening,the zinc nicotinate coordination polymer[Zn(nicotinate)2]n([Zn(NA)2])was found to have the best overall performance,and the optimal ad-sorption and desorption conditions were determined.The results showed that the optimal adsorption condi-tions were adsorption time of 6 h,pH value of sample stock solution of 5.0,and concentration of sample stock solution of 2.20 mg/mL,and the adsorption amount of total flavonoids of Cistanchis sinensis by[Zn(NA)2]was62.91 mg/g.The optimal desorption condition was a30%ethanol solution,and the desorp-tion rate was 45.52%.The purity of total flavonoids in Cistanche was increased from 9.33%to 48.23%after adsorption and desorption.The crystalline form of[Zn(NA)2]before and after adsorption and de-sorption was characterized by PXRD as stable.The experiments showed that[Zn(NA)2]exhibited high adsorption performance with efficient enrichment and purification of flavonoids from Cistanche.Therefore,MOFs possess a wide range of application prospects as emerging materials for the enrichment and separa-tion of active ingredients in traditional Chinese medicine.
metal organic frameworks(MOFs)Cistanche deserticolatotal flavonoids
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