The performance of different MOFs in the enrichment and separation of total flavonoids from Cistanche deserticola Y.C.Ma and the optimal adsorption and resolution conditions was investigated.Five MOFs,[Zn(nicotinate)2]n,MIL-101(Cr),MIL-101(Fe),MIL-53(Fe)and MOF-5,were synthesized by hydrothermal synthesis,and characterized by PXRD,FTIR,SEM and TG to ensure the accurate synthesis,and the adsorption and desorption quantities under different conditions were taken as the indexes for eval-uating adsorption and desorption performance.After screening,the zinc nicotinate coordination polymer[Zn(nicotinate)2]n([Zn(NA)2])was found to have the best overall performance,and the optimal ad-sorption and desorption conditions were determined.The results showed that the optimal adsorption condi-tions were adsorption time of 6 h,pH value of sample stock solution of 5.0,and concentration of sample stock solution of 2.20 mg/mL,and the adsorption amount of total flavonoids of Cistanchis sinensis by[Zn(NA)2]was62.91 mg/g.The optimal desorption condition was a30%ethanol solution,and the desorp-tion rate was 45.52%.The purity of total flavonoids in Cistanche was increased from 9.33%to 48.23%after adsorption and desorption.The crystalline form of[Zn(NA)2]before and after adsorption and de-sorption was characterized by PXRD as stable.The experiments showed that[Zn(NA)2]exhibited high adsorption performance with efficient enrichment and purification of flavonoids from Cistanche.Therefore,MOFs possess a wide range of application prospects as emerging materials for the enrichment and separa-tion of active ingredients in traditional Chinese medicine.
关键词
金属有机框架(MOFs)/肉苁蓉/总黄酮
Key words
metal organic frameworks(MOFs)/Cistanche deserticola/total flavonoids
万方数据