Preparation and properties of P(NIPAm-co-AA)hydrogel
Polysuccinimide(PSI)was synthesized from L-polyaspartic acid by thermal polycondensation reaction.The crosslinking agent acryloxyethylamine polysuccinimide(AEA-PSI)was obtained by the reac-tion of PSI with ethanol and acrylylation PSI reacted with ethanol.The P(NIPAm-co-AA)hydrogel was synthesized with N-isopropylacrylamide(NIPAm)and acrylic acid(AA)as monomers and AEA-PSI as crosslinkers.The drug sustained release and biodegradation properties of P(NIPAm-co-AA)hydrogel were studied.The results showed that when the NIPAm/AA molar ratio of P(NIPAm-co-AA)hydrogel was 92/8,the dosage of AEA-PSI was 4%,and the temperature was 37℃,the sustained release effect of P(NIPAm-co-AA)hydrogel was the best,and the sustained release rate reached 60%within 24 h.The addition of pepsin had no significant effect on the sustained release rate of the drug.The degradation rate of P(NIPAm-co-AA)hydrogel in simulated gastric fluid was higher than that in simulated intestinal fluid,and the degradation rate of P(NIPAm-co-AA)hydrogel in simulated gastric fluid reached more than 15%within 24 h.
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