Therapeutic effects of LC+LTCBDE and ERCP/EST+LC in the treatment of patients with cholecysto-lithiasis with choledocholithiasis
Objective:To compare the therapeutic effects of laparoscopic cholecystectomy(LC)+laparoscopic tran-scystic common bile duct exploration(LTCBDE)and endoscopic retrograde cholangiopancreatography(ERCP)/endo-scopicsphinctectoy(EST)+LC in patients with cholecystolithiasis with choledocholithiasis.Methods:The clinical data of 118 patients with cholecystolithiasis with choledocholithiasis treated from July 2021 to February 2024 were retro-spectively collected,and they were divided into group A(n=64)and group B(n=54)according to different surgical methods.The former was treated with LC+LTCBDE,and the latter was treated with ERCP/EST+LC.The periopera-tive related indexes were compared between the two groups,as well as biochemical indexes[alkaline phosphatase(ALP),alanine aminotransferase(ALT),total bilirubin(TBIL),glutamyl transpeptidase(GGT)],inflammatory reac-tion[interleukin-10(IL-10),substance P(SP),interleukin-8(IL-8)]before and after operation,and complica-tions were also compared between the two groups.Results:Compared with group B,group A had shorter hospitalization time,shorter drainage retention time,shorter first exhaust time,less hospitalization expenses,longer operation time and more bleeding(P＜0.05).Compared with group B,the levels of serum ALP,ALT,TBIL and GGT in group A were lower at 7 d after operation(P＜0.05).Compared with group B,the levels of serum SP and IL-8 were lower and the level of IL-10 was higher in group at 7 d after operation(P＜0.05).The incidence of complications in group A was lower than that in group B(P＜0.05).Conclusion:LC+LTCBDE for patients with gallstones and choledocholithiasis can improve biochemical indicators,reduce inflammatory reactions in the body,promote rapid recovery,and has good safety.
cholecystolithiasis with choledocholithiasisendoscopic retrograde cholangiopancreatographyendo-scopicsphinctectoylaparoscopic cholecystectomylaparoscopic transcystic common bile duct exploration
万方数据
维普
