To investigate the effect of composite nanofiber membrane prepared from isoorientin(ISO)and zein/Arabic gum(GA)on skin injury healing in mice,this study used blank spinning membrane as control,and wound dressings were applied to mice using zein/GA loaded nanofiber membrane,ISO loaded nanofiber membrane,and ISO-zein/GA loaded composite nanofiber membrane,respectively.The results showed that the nanofiber membranes loaded with zein/GA,ISO and ISO-zein/GA had promoting effects on wound healing in mice.They effectively reduced wound oxidative damage and mRNA expression levels of pro-inflammatory factors(TNF-α、IL-1β、iNOS),and promoted wound vascular reconstruction,thereby accelerating wound healing.The research results verify the promoting effect of ISO-zein/GA composite nanofiber membrane on wound healing,expand the application range of isoorientin,and provide ideas for the research of new wound dressing.
维普
万方数据