Against the backdrop of the national development strategy driven by innovation,open and innovative experimental teaching in universities has become a key platform for cultivating innovative and practical high-quality talents.This paper analyzes the experi-mental safety risks due to the openness of experimental themes,materials,reagents,equipment,venues,and time in innovative exper-imental teaching,and it proposes to establish an open and innovative experimental safety management system starting from three as-pects:establishing a special safety management system,strengthening safety education,and implementing safety risk assessments for experimental projects.This system aims to ensure the safety and quality of experimental teaching while supporting educational innova-tion.