现代检验医学杂志2024，Vol.39Issue(1) ：61-66.DOI:10.3969/j.issn.1671-7414.2024.01.011

精神分裂症患者血清P2X7R和CTGF水平表达与临床症状评分及认知功能的相关性研究

Correlation between the Expression of Serum P2X7R and CTGF Levels and Clinical Symptom Scores and Cognitive Function in Patients with Schizophrenia

桂秀 陶璃娜 乔娟 陈芬
现代检验医学杂志2024，Vol.39Issue(1) ：61-66.DOI:10.3969/j.issn.1671-7414.2024.01.011
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精神分裂症患者血清P2X7R和CTGF水平表达与临床症状评分及认知功能的相关性研究

Correlation between the Expression of Serum P2X7R and CTGF Levels and Clinical Symptom Scores and Cognitive Function in Patients with Schizophrenia

桂秀 1陶璃娜 1乔娟 1陈芬2
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作者信息

  • 1. 武汉市武东医院精神重症一科,武汉 430000
  • 2. 华中科技大学同济医学院附属协和医院心内科,武汉 430022;生物靶向治疗研究湖北省重点实验室,武汉 430022;心血管疾病免疫诊疗湖北省工程研究中心,武汉 430022
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摘要

目的 探究血清嘌呤能离子通道型受体 7(purinergic ligand-gated ion channel 7 receptor,P2X7R)、结缔组织生长因子(connective tissue growth factor,CTGF)表达与精神分裂症患者认知功能、临床症状的相关性.方法 选取2021年1 月～2023 年 1 月在武汉市武东医院精神重症一科诊治的 160 例精神分裂症患者作为观察组,及同期 160 例健康体检志愿者作为对照组进行研究.根据阳性和阴性症状量表(positive and negative syndrome scale,PANSS)对患者精神临床症状(阳性和阴性症状、一般病理症状、附加症状)进行评估,将患者分为高分组(PANSS总分≥70 分,n=72)和低分组(PANSS总分＜70 分,n=88).利用精神分裂症认知功能成套测验共识版(MATRICS consensus cognitive battery,MCCB)评估患者认知能力;采用酶联免疫吸附测定(ELISA)法检测血清P2X7R和CTGF水平;Spearman法分析精神分裂症患者血清P2X7R和CTGF水平与PANSS各项评分、MCCB各项评分的相关性.结果 与对照组相比,观察组血清P2X7R(610.71±107.83ng/L vs 384.78±80.62ng/L),CTGF水平(1.85±0.36µg/L vs 1.40±0.21µg/L)升高,差异有统计学意义(t=21.226,13.658,P＜0.05);观察组精神分裂症患者MCBB各项评分均低于对照组,差异有统计学意义(t=14.845～24.862,均P＜0.05);高分组精神分裂症患者阳性症状评分(21.10±3.42分)、阴性症状评分(23.37±5.03分)、一般病理症状评分(39.48±8.11 分)、附加症状评分(8.26±1.22 分)和PANSS总分(92.21±12.50 分)均高于低分组(13.65±3.04分,15.62±3.91分,30.14±6.15分,5.20±0.94分,64.61±5.30分),差异有统计学意义(t=14.576,10.964,8.280,17.915,18.764,均P＜0.05);高分组精神分裂症患者血清P2X7R,CTGF水平高于低分组,差异有统计学意义(t=12.233,5.923,均P＜0.05);精神分裂症患者血清P2X7R,CTGF水平与PANSS各项评分均呈正相关(r=0.464～0.580,均P＜0.05),与MCCB各项评分均呈负相关(r=-0.603～-0.439,均P＜0.05).结论 精神分裂症患者血清P2X7R和CTGF水平升高,与患者临床症状和认知功能密切相关.

Abstract

Objective To investigate the correlation between the expression of purinergic ligand-gated ion channel 7 receptor(P2X7R)and connective tissue growth factor(CTGF)in serum and cognitive function and clinical symptoms in patients with schizophrenia.Methods A total of 160 patients with schizophrenia who were diagnosed and treated in Department of Mental Intensive Care of Wuhan Wudong Hospital from January 2021 to January 2023 were collected as the observation group,and 160 healthy volunteers who underwent physical examinations were collected as the control group for the study.According to the Positive and Negative Symptom Scale(PANSS),patients were evaluated for their clinical and psychiatric symptoms(positive and negative symptoms,general pathological symptoms,and additional symptoms).The patients were grouped into a high score group(PANSS total score≥70 points,n=72)and a low score group(PANSS total score＜70 points,n=88).MATRICS consensus cognitive battery(MCCB)was applied to evaluate the cognitive abilities of patients;enzyme-linked immunosorbent assay(ELISA)was applied to detect serum P2X7R and CTGF levels.Spearman method was applied to analyze the correlation between serum P2X7R,CTGF levels and PANSS scores,and MCCB scores in patients with schizophrenia.Results Compared with the control group,the serum levels of P2X7R(610.71±107.83ng/L vs 384.78±80.62 ng/L)and CTGF(1.85±0.36µg/L vs 1.40±0.21µg/L)in the observation group were increased,with differences of statistical significance(t=21.226,13.658,all P＜0.05).The scores of variety items of MCBB of patients with schizophrenia in the observation group were lower than those in the control group,with differences of statistical significance(t=14.845～24.862,all P＜0.05),the positive symptom score(21.10±3.42score),negative symptom score(23.37±5.03 score),general pathological symptom score(39.48±8.11score),additional symptom score(8.26±1.22 score),and PANSS total score(92.21±12.50score)of schizophrenia patients in the high group were higher than those in the low group(13.65±3.04,15.62±3.91 score,30.14±6.15 score,5.20±0.94score,64.61±5.30score),with differences of statistical significance(t=14.576,10.964,8.280,17.915,18.764,all P＜0.05).The serum levels of P2X7R and CTGF in patients with schizophrenia in the high group were higher than those in the low group,with differences of statistical significance(t=12.233,5.923,all P＜0.05).The levels of serum P2X7R and CTGF in patients with schizophrenia were positively correlated with PANSS score(r=0.464～0.580,all P＜0.05),and negatively correlated with MCCB score[r=-0.603～-0.439,all P＜0.05].Conclusion The serum levels of P2X7R and CTGF in patients with schizophrenia are elevated,they are closely related to the clinical symptoms and cognitive function of patients.

关键词

精神分裂症/嘌呤能离子通道型受体/7/结缔组织生长因子/认知功能

Key words

schizophrenia/purinergic ligand-gated ion channel 7 receptor/connective tissue growth factor/cognitive function

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基金项目

国家自然科学基金(81300196)

湖北省科技厅项目(2020CFB765)

出版年

2024
现代检验医学杂志
陕西省临床检验中心,陕西省人民医院

现代检验医学杂志

CSTPCD
影响因子：0.713
ISSN：1671-7414
参考文献量13
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