现代检验医学杂志2024，Vol.39Issue(1) ：83-89.DOI:10.3969/j.issn.1671-7414.2024.01.015

肝细胞肝癌患者血清LG2m和hPG80表达水平及临床价值研究

Study on the Expression Levels and Clinical Value of Serum LG2m and hPG80 in Patients with Hepatocellular Carcinoma

刘宏 张春华 阳宏 王万琴
现代检验医学杂志2024，Vol.39Issue(1) ：83-89.DOI:10.3969/j.issn.1671-7414.2024.01.015
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肝细胞肝癌患者血清LG2m和hPG80表达水平及临床价值研究

Study on the Expression Levels and Clinical Value of Serum LG2m and hPG80 in Patients with Hepatocellular Carcinoma

刘宏 1张春华 1阳宏 1王万琴1
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作者信息

  • 1. 成都市双流区第一人民医院/四川大学华西空港医院消化内科,成都 610200
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摘要

目的 研究肝细胞肝癌(hepatocellular carcinoma,HCC)患者血清层黏连蛋白γ2 单体(laminin gamma 2 monomer,LG2m)、人循环前胃泌素(human circulating gastrin,hPG80)表达水平及临床价值.方法 选取2016年1月～2018年 1 月成都市双流区第一人民医院收治的 128 例HCC患者为HCC组,以同期诊治的 70 例肝脏良性病变患者为良性病变组,以同期体检的 70 例健康人为对照组.应用酶联免疫吸附试验检测血清LG2m和hPG80 水平.受试者工作特征(ROC)曲线分析血清LG2m和hPG80 对HCC患者预后的评估价值.Kaplan-Meier生存分析比较不同血清LG2m和hPG80水平HCC患者生存预后差异.COX回归分析影响HCC患者预后的因素.结果 HCC组血清LG2m(28.14±3.10 ng/L),hPG80(84.83±11.39 ng/L)水平高于良性病变组(9.18±1.74 ng/L,25.10±4.11 ng/L)和对照组(8.24±1.65 ng/L,23.15±3.26 ng/L),差异具有统计学意义(t=68.240～76.635,均P＜0.05).TNM分期Ⅲ期、低分化程度、血清AFP＞400μg/L患者血清LG2m,hPG80 水平高于TNM分期I～Ⅱ期、高中分化程度、AFP≤400μg/L患者,差异具有统计学意义(t=3.216～13.552,均P＜0.05).血清LG2m,hPG80联合检测对HCC患者预后评估的曲线下面积(95%CI)为 0.934(0.889～0.961),大于单项指标检测 0.813(0.774～0.849),0.896(0.840～0.937).血清LG2m高表达和低表达HCC患者的五年总体生存率分别为 33.33%(21/63),67.69%(44/65).与血清LG2m低表达HCC患者相比,血清LG2m高表达HCC患者五年累积生存率更低(Log-Rankχ2=19.522,P＜0.05).血清hPG80 高表达和低表达HCC患者的五年总体生存率分别为 35.48%(22/62),65.15%(43/66).与血清hPG80 低表达HCC患者相比,血清hPG80高表达HCC患者五年累积生存率更低(Log-Rankχ2=12.546,P＜0.05).TNM分期Ⅲ期(OR=1.487,P＜0.05)、低分化程度(OR=1.611,P＜0.05)、血清AFP≥400μg/L(OR=1.416,P＜0.05)、血清LG2m(OR=1.838,P＜0.05)高表达、hPG80(OR=1.735,P＜0.05)高表达是HCC患者不良预后的独立危险因素.结论 HCC患者血清LG2m和hPG80水平升高,两者与TNM分期、肿瘤分化程度及血清AFP水平有关,是评估HCC患者生存预后的血清标志物.

Abstract

Objective To study the serum laminin γ 2 monomer(LG2m),human circulating Gastrin(hPG80)in patients with hepatocellular carcinoma(HCC)and their clinical value.Methods 128 HCC patients admitted to the First People's Hospital of Shuangliu District from January 2016 to January 2018 were selected as the HCC group,70 patients with benign liver lesions diagnosed and treated at the same time were selected as the benign lesion group,and 70 healthy individuals who underwent physical examinations during the same time were selected as the control group.Use enzyme-linked immunosorbent assay to detect serum LG2m and hPG80 levels.The evaluation value of serum LG2m and hPG80 in predicting the prognosis of HCC patients were analyzed by receiver operating characteristic curve.Kaplan-Meier survival analysis was used to compare the survival prognosis of HCC patients with different serum LG2m and hPG80 levels.COX regression analysis was used to analyze the prognostic factors of HCC patients.Results The levels of serum LG2m(28.14±3.10 ng/L),hPG80(84.83±11.39 ng/L)in the HCC group were higher than those in the benign lesion group(9.18±1.74 ng/L,25.10±4.11 ng/L)and the control group(8.24±1.65 ng/L,23.15±3.26 ng/L),and the differences were statistically significant(t=68.240～76.635,all P＜0.05).The levels of serum LG2m and hPG80 in patients with TNM stage III,low differentiation degree,serum AFP＞400 μg/L were higher than those in TNM stage I to II,high differentiation,AFP≤400 μg/L,the differences were statistically significant(t=3.216～13.552,all P＜0.05).The area under the curve(95%CI)of the combined evaluation of serum LG2m and hPG80 for the prognosis of HCC patients was 0.934(0.889～0.961),which was greater than the single indicator of 0.813(0.774～0.849)and 0.896(0.840～0.937).The overall 5-year survival rates of HCC patients with high and low serum LG2m expression were 33.33%(21/63)and 67.69%(44/65),respectively.Compared with HCC patients with low expression of serum LG2m,HCC patients with high expression of serum LG2m had a lower 5-year cumulative survival rate(Log-Rankχ2=19.522,P＜0.05).The overall 5-year survival rates of HCC patients with high and low serum hPG80 expression were 35.48%(22/62)and 65.15%(43/66),respectively.Compared with HCC patients with low serum hPG80 expression,HCC patients with high serum hPG80 expression had a lower 5-year cumulative survival rate(Log-Rankχ2=12.546,P＜0.05).TNM stage III(OR=1.487,P＜0.05),low differentiation degree(OR=1.611,P＜0.05),serum AFP≥400μg/L(OR=1.416,P＜0.05),high expression of serum LG2m(OR=1.838,P＜0.05),and high expression of hPG80(OR=1.735,P＜0.05)were independent risk factors for poor prognosis in HCC patients.Conclusion The serum levels of LG2m and hPG80 in HCC patients increase,which are related to TNM staging,tumor differentiation,and serum AFP levels.They are serum biomarkers for evaluating the survival and prognosis of HCC patients.

关键词

肝细胞肝癌/层黏连蛋白γ2单体/人循环前胃泌素

Key words

hepatocellular carcinoma/laminin gamma 2 monomer/human circulating gastrin

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基金项目

四川省医学卫生健康科研课题(19PJ065)

出版年

2024
现代检验医学杂志
陕西省临床检验中心,陕西省人民医院

现代检验医学杂志

CSTPCD
影响因子：0.713
ISSN：1671-7414
参考文献量4
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