噬菌体抗细菌生物膜机制及应用策略的研究进展
Advances in the Mechanism of Phage Resistance to Bacterial Biofilms and Strategies for Its Application
杨佩霓 1李庆蓉 1李江 1何薇 1和平安 1吕梅 1杨旭1
作者信息
- 1. 昆明医科大学第二附属医院检验科,昆明 650032
- 折叠
摘要
细菌生物膜(bacterial biofilms,BF)是细菌在生物或非生物表面所形成的复杂微生物群落,其形成显著增强了细菌毒力和耐药性,与高比例的慢性细菌感染相关,对人类健康造成严重威胁.传统抗生素和常用消毒剂在清除生物膜方面的能力有限,迫切需要一种有效的新策略治疗细菌生物膜.噬菌体(bacteriophage,phage)作为一类能感染并裂解细菌的病毒,具有较高的安全性和特异度,被认为是治疗细菌生物膜有前景的替代方法.该文综述了噬菌体抗细菌生物膜的作用机制、基于噬菌体及其衍生物在防控细菌生物膜形成的应用策略,为开发高效的噬菌体抗细菌生物膜方法提供新思路.
Abstract
Bacterial biofilms(BF)are complex microbial communities formed by bacteria on living or abiotic surfaces.Their formation significantly enhances bacterial virulence and drug resistance and is associated with a high proportion of chronic bacterial infections,posing a serious threat to human health.The ability of traditional antibiotics and commonly used disinfectants to clear biofilms is limited,and an effective new strategy to treat BF is urgently needed.Bacteriophage,as a kind of virus that can infect and lyse bacteria,has high safety and specificity,and is considered as a promising alternative method for the treatment of BF.In this paper,the mechanism of bacteriophage anti-bacterial biofilm and the application strategies based on bacteriophage and its derivatives in the prevention and control of bacteriophage biofilm formation were reviewed,which provided new ideas for the development of efficient bacteriophage anti-bacterial biofilm methods.
关键词
噬菌体/细菌生物膜/噬菌体抗细菌生物膜机制/噬菌体应用Key words
phage/bacterial biofilm/bacteriophage anti-bacterial biofilm mechanism/phage application引用本文复制引用
基金项目
国家自然科学基金(82060669)
云南省科技厅-基础研究专项面上项目(202101AT070256)
云南省教育厅科研项目(2023Y0641)
昆明医科大学第二附属医院内科技计划(2021yk002)
昆明医科大学2023研究生创新基金(2023)(2023S315)
出版年
2024
国家科技期刊平台
NSTL
维普
万方数据