Objective To explore the relationship between serum Sestrin 2,soluble vascular endothelial growth factor receptor-1(sFlt-1)levels and cognitive function and prognosis in patients with gerontic vascular dementia.Methods A total of 107 patients with gerontic vascular dementia treated in West China Hospital of Sichuan University from January 2021 to January 2023 were selected as the study group,and 107 healthy individuals who underwent physical examinations during the same period were selected as the control group.Enzyme-linked immunosorbent assay(ELISA)method was used to detect the expression level of serum Sestrin 2 and sFlt-1.Different Minimum Mental State Examination(MMSE)scores were used to compare the serum Sestrin 2 and sFlt-1 levels of patients.Correlation between the serum Sestrin 2,sFlt-1 levels and the MMSE scores was analyzed by Spearman method.The differences in serum Sestrin 2 and sFlt-1 levels in patients with gerontic vascular dementia with different prognostic dysfunction grades were compared,and the predictive value of serum Sestrin 2,sFlt-1 for prognostic dysfunction in patients with gerontic vascular dementia was analyzed by the receiver operating characteristic(ROC)curve.Results Serum Sestrin 2(15.57±1.56ng/ml)and sFlt-1(35.68±1.56pg/ml)expression levels were higher in the study group than those in the control group(11.68±1.46ng/ml,25.48±2.32pg/ml),the differences were statistically significant(t=18.833,21.363,all P＜0.05).Serum Sestrin 2 and sFlt-1 levels were decreased in the patients in study group as the MMSE score increased,and the differences were statistically significant(F=134.682,29.284,all P＜0.05).Serum Sestrin 2 and sFlt-1 levels were negatively correlated with MMSE scores(r=-0.587,-0.554,all P＜0.05).Serum Sestrin 2 and sFlt-1 levels of patients withprognostic dysfunction grading Ⅲ were higher than those in patients with grades Ⅰ-Ⅱ(t=8.745,10.018,all P＜0.05).AUC predicted by combination of Sestrin2 and sFlt-1 was greater than AUC predicted by Sestrin 2 and sFlt-1 alone(Z=2.348,2.059,P=0.019,0.040).Conclusion Serum levels of Sestrin 2 and sFlt-1 are elevated in patients with gerontic vascular dementia,and they are closely related to cognitive function.The combination of the two may have certain prognostic value.
Sestrin 2soluble vascular endothelial growth factor receptor-1gerontic vascular dementiacognitive function
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