Correlation of Serum Asprosin,MIP-1 β Levels with Bone Mineral Density and Bone Metabolism Indexes in Patients with Type 2 Diabetes Mellitus Combined with Osteoporosis
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维普
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目的 探究2型糖尿病并发骨质疏松患者血清白脂素(Asprosin)、巨噬细胞炎症蛋白-1β(macrophage inflammato-ry protein-1 β,MIP-1 β)水平与骨密度及骨代谢指标的相关性.方法 选取2022年4月～2023年4月在承德市中心医院就诊的172例2型糖尿病患者为研究对象,并根据骨密度值结果分为2型糖尿病组(n=103)和2型糖尿病并发骨质疏松组(n=69);采用ELISA法测定血清Asprosin,MIP-1 β水平;Pearson法分析血清Asprosin,MIP-1 β表达水平与骨密度的相关性;Logistic回归分析2型糖尿病并发骨质疏松的影响因素;受试者工作特征(ROC)曲线分析血清Asprosin,MIP-1 β水平对2型糖尿病并发骨质疏松的预测价值.结果 与2型糖尿病组比,2型糖尿病并发骨质疏松组患者血清 β-CTX(0.48±0.08ng/ml vs 0.42±0.04ng/ml),Asprosin(2.26±0.56ng/ml vs 1.65±0.36ng/ml),MIP-1 β(26.01±6.43pg/ml vs 19.46±4.27pg/ml)水平均显著升高,骨密度(0.67±0.13g/cm2 vs 0.84±0.17g/cm2),BGP(8.33±1.23ng/ml vs 9.54±1.42ng/ml),T-P1NP(30.38±3.27ng/ml vs 32.49±3.29ng/ml)水平降低,差异具有统计学意义(t=6.501,8.699,8.032,7.039,5.773,4.133,均P＜0.05);Pearson法分析显示,2型糖尿病并发骨质疏松组患者血清Asprosin,MIP-1 β水平均与骨密度呈负相关(r=-0.484,-0.498,均P＜0.05);Logistic回归分析显示血清Asprosin,MIP-1 β水平均为影响2型糖尿病并发骨质疏松发生的独立危险因素(均P＜0.05);ROC曲线分析显示,血清Asprosin,MIP-1 β水平预测2型糖尿病患者并发骨质疏松的AUC分别为0.768,0.704,联合预测的AUC为0.859,优于二者单独预测(Z=1.812,2.895,均P＜0.05).结论 2型糖尿病患者并发骨质疏松患者血清Asprosin,MIP-1 β水平显著升高,二者水平与骨密度密切相关,血清Asprosin,MIP-1 β是2型糖尿病发生骨质疏松的独立危险因素,二者联合检测对疾病发展有较高的预测价值.
Objective To investigate the correlation between serum Asprosin,macrophage inflammatory protein-1 β(MIP-1 β)levels and bone mineral density and bone metabolism indexes in patients with type 2 diabetes mellitus(T2DM)combined with osteoporosis.Methods A tatal of 172 patients with T2DM attending Chengde City Central Hospital from April 2022 to April 2023 were selected for the study,and they were divided into T2DM group(n=103)and T2DM combined with osteoporosis group(n=69)according to the results of bone mineral density.Serum Asprosin and MIP-1 β levels were measured by ELISA.Pearson method was used to analyze the correlation between serum Asprosin,MIP-1 β expression levels and bone mineral density.Logistic regression was used to analyze the factors affecting T2DM combined with osteoporosis,and the receiver operating characteristic(ROC)curve was used to analyze the predictive value of serum Asprosin and MIP-1 β level on T2DM combined with osteoporosis.Results Compared with the T2DM group,patients in the T2DM combined with osteoporosis group had higher levels of serum β-CTX(0.48±0.08ng/ml vs 0.42±0.04ng/ml),Asprosin(2.26±0.56ng/ml vs 1.65±0.36ng/ml)and MIP-1 β(26.01±6.43pg/ml vs 19.46±4.27pg/ml),while BMD(0.67±0.13g/cm2 vs 0.84±0.17g/cm2),BGP(8.33±1.23ng/ml vs 9.54±1.42ng/ml)and T-P1NP(30.38±3.27ng/ml vs 32.49±3.29ng/ml)levels were decreased,with statistically significant differences(t=6.501,8.699,8.032,7.039,5.773,4.133,all P＜0.05).Pearson method analysis showed that serum Asprosin and MIP-1 β levels were negatively correlated with bone mineral density of patients in the T2DM combined with osteoporosis group(r=-0.484,-0.498,all P＜0.05).Logistic regression analysis showed that serum Asprosin and MIP-1 βlevels were independent risk factors influencing the occurrence of T2DM combined with osteoporosis(all P＜0.05).ROC curve analysis showed that the AUCs of serum Asprosin and MIP-1 β levels predicted T2DM combined osteoporosis were 0.768 and 0.704,respectively,and the AUC of both combined prediction was 0.859,which was better than the two alone(Z=1.812,2.895,all P＜0.05).Conclusion Serum Asprosin and MIP-1 β levels are elevated in patients with T2DM combined with osteoporosis,and both are closely related to bone mineral density.Serum Asprosin and MIP-1 β are independent risk factors for the development of T2DM combined with osteoporosis,and the joint detection of the two tests may have high predictive value for the development of the disease.
维普
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