Effects of thoracoscopic lobectomy on immune function and inflammatory response in patients with non-small cell lung cancer
Objective To investigate the effects of thoracoscopic lobectomy on immune function and serum levels of procalcitonin(PCT),interleukin(IL)-8 and IL-6 in patients with non-small-cell lung cancer(NSCLC).Methods Ninety-eight patients with NSCLC in Chengdu People's Hospital from January 2019 to December 2020 were selected as the research object and were divided into the control group and the study group according to different surgical methods,including the control group(49 patients receiving conventional thoracotomy)and the study group(49 patients receiving thoracoscopic lobectomy).Both groups were observed until discharge and followed up for 3 months.Clinical indexes,immune function and serum PCT,IL-8 and IL-6 levels before and 3 days after surgery,and life quality scores before and 3 months after surgery were observed and compared between the two groups.Results The operation time and incision length of the study group were shorter than those in the control group,and the intraoperative blood loss and postoperative drainage on the same day were lower than those of the control group(P＜0.05).There was no statistical significance in the number of intraoperative lymph node dissection between the two groups(P＞0.05).Before the operation,there was no significant difference in the levels of CD3+,CD4+,CD8+and CD4+/CD8+between the two groups(P＞0.05).The plasma levels of CD3+,CD4+,CD8+and CD4+/CD8+of the study group were higher than those of the control group 3 days after the operation(P＜0.05).Before the operation,there was no significant difference in the levels of serum PCT,IL-8 and IL-6 between the two groups(P＞0.05).The levels of serum PCT,IL-8 and IL-6 of the study group were lower than those of the control group 3 days after operation(P＜0.05).Before the operation,there was no significant difference in the scores of body,role,emotion,cognition and social function between the two groups(P＞0.05).The scores of body,role,emotion,cognition and social function of the study group were higher than those of the control group 3 months after operation(P＜0.05).Conclusion Thoracoscopic lobectomy can effectively relieve clinical symptoms in patients with NSCLC,optimize surgical indicators,reduce the impact of surgery on immune function and inflammatory response,and improve quali-ty of life and clinical efficacy.
万方数据
维普
