Effect of penehyclidine aerosol inhalation combined with vibration expectorator on patients with pulmonary infection after intracerebral hemorrhage
Objective To investigate the effect of penehyclidine aerosol inhalation combined with a vibration expectorator on glutathione peroxidase(GSH-Px)and total antioxidant capacity(T-AOC)in patients with pulmonary infection after intracerebral hemorrhage.Methods A random number table method was used to divide 130 postoperative pulmonary infection patients with cerebral hemorrhage who visited our hospital from January 2021 to December 2022 into a study group(n=65)and a control group(n=65).The control group received routine treatment,while the study group received a vibration sputum ejection machine combined with nebulized inhalation of penehyclidine for treatment on this basis.The hospitalization time,mechanical ventilation time,lung rale relief time,and cough relief time of the two groups were observed,and the sputum output,sputum properties,blood gas indicators,inflammatory factors,GSH-Px,and T-AOC before and after treatment between the two groups were compared.Results The hospitalization time,mechanical ventilation time,lung rale relief time,and cough relief time of the study group were shorter than those of the control group,and the differences were statistically significant(P＜0.05).The sputum output and properties of the two groups after 24 hours of treatment were better than those before treatment,and the research group was better than the control group,the differences were statistically significant(P＜0.05).After treatment,oxygen saturation and PaO2 in both groups were higher than those before treatment,and PaCO2 in arterial blood was lower than that before treatment,the study group was better than the control group,the differences were statistically significant(P＜0.05).Tumor necrosis factor α(TNF-α),interleukin-1 β(IL-1β),and IL-6 of the two groups after treatment were lower than that be-fore treatment,and the study group was lower than those the control group,and the differences were statistically significant(P＜0.05).After treatment,GSH-Px and T-AOC in both groups were higher than those before treat-ment,and those the study group were higher than the control group,the differences were statistically significant(P＜0.05).Conclusion Penehyclide aerosol inhalation combined with a vibration expectorator can significantly shorten the hospital stay of patients with pulmonary infection after intracerebral hemorrhage,adjust the body blood gas index,and increase the level of GSH-Px and T-AOC.
万方数据
维普
