Effect of indobufen combined with infrared radiation on improving coagulation status,vascular endothelial function and arteriovenous fistula function in hemodialysis patients
Objective To explore the effect of indobufen combined with infrared radiation on improving coagulation status,vascular endothelial function,and arteriovenous fistula function in hemodialysis patients.Methods One hundred and ninety-two patients with maintenance hemodialysis(MHD)who established arterio-venous fistula(AVF)in the Nephrology Department of our hospital were divided into two groups by random number table.The control group was treated with infrared radiation every day after AVF was established,and the study group was treated with indobufen in addition to infrared radiation.The lipid[total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C)],blood coagulation function[part activated clotting time(APTT),whole blood viscosity,fibrinogen(Fib),platelet aggregation rate],and blood Endovascular function[endothelin-1(ET-1),nitric oxide(NO),vascular endothelial growth factor-A(VEGF-A)]was compared in the two groups before and after the intervention.The vascular maturation rate,internal fistula blood flow,and vascular patency rate were statistically compared between the two groups after 1 month of intervention.Results Compared to the control group,the study group was treated with serum lipid TG[(4.16±1.24)mmol/L vs(4.32±1.10)mmol/L],TG[(1.59±0.40)mmol/L vs(1.59±0.42)mmol/L]and LDL-C[(2.40±0.60)mmol/L vs(2.43±0.69)mmol/L],HDL-C[(1.28±0.37)mmol/L vs(1.26±0.33)mmol/L]had no significant changes(P＞0.05),the APTT[(33.9±2.2)s vs(31.9±2.3)s]was significantly prolonged,whole blood viscosity[(4.72±0.43)mPa·s vs(5.08±0.47)mPa·s],serum Fib[(3.10±0.28)μmol/L vs(3.40±0.27)μmol/L],platelet aggregation rate[50.7±5.3)％vs(56.5±4.7)％]were significantly decreased(P＜0.05),the lev-el of serum ET-1[(62±14)μmol/L vs(72±14)μmol/L],NO[(90±12)µmol/L vs(80±12)μmol/L]decreased,and the level of VEGF-A[(191±47)pg/ml vs(218±43)pg/ml]increased significantly(P＜0.05).There was no signifi-cant difference in vascular maturity rate between the two groups(74.0％vs 70.8％)(P＞0.05).However,the blood flow[(277±31)ml vs(257±33)ml]and the vascular patency rate(99.0％vs 87.5％)in the study group were significantly higher than those in the control group(P＜0.05).Conclusion Indobufen combined with infrared radiation can inhibit platelet aggregation,regulate the coagulation state and vascular endothelial function,prevent AVF stenosis,and improve the patency rate of internal fistula without significantly affecting blood lipids.
万方数据
维普
