Correlation analysis of serum CEA,CYFRA21-1,FIB,D-dimer and prealbumin with the prognosis of patients with non-small cell lung cancer chemotherapy
Objective To analyze the correlation between serum carcinoembryonic antigen(CEA),cytokeratin 19 soluble fragment(CYFRA21-1),fibrinogen(FIB),D-dimer(D-D),and prealbumin(PAB)and the prognosis of patients with non-small cell lung cancer(NSCLC)chemotherapy.Methods A retrospective study was conducted to select the clinical data of 120 NSCLC patients who were treated with chemotherapy in the hospital from June 2021 to June 2023 as the study subjects.All patients received cisplatin+gemcitabine(GD)chemotherapy and were followed up for 12 months.According to the survival during the follow-up period,the clinical data of the surviving patients were included in the good prognosis group,and the clinical data of the dead patients were included in the poor prognosis group.Serum CEA,CYFRA21-1,FIB,D-D,and PAB were detected on admission,and the baseline data of the patients were statistically analyzed.Bivariate correlation Pear-son(N)analysis was used to analyze the relationship between serum CEA,CYFRA21-1,FIB,D-D,PAB levels and survival of NSCLC patients undergoing chemotherapy.Binary logistic regression analysis was used to analyze the correlation between serum CEA,CYFRA21-1,FIB,D-D,and PAB levels and poor prognosis in patients with NSCLC chemotherapy.The results of the receiver operating characteristic(ROC)curve showed that the levels of serum CEA,CYFRA21-1,FIB,D-D,and PAB predicted the poor prognosis of patients with NSCLC chemothera-py.The dose-response relationship between serum CEA,CYFRA21-1,FIB,D-D,and PAB levels and poor prog-nosis of NSCLC patients undergoing chemotherapy was analyzed by using the restricted cubic spline method com-bined with spline function and Logistics regression.Results The proportion of patients with poor differentiation and clinical stage Ⅲ-Ⅳ in the poor prognosis group was higher than that in the good prognosis group,CEA,CYFRA21-1,FIB,and D-D were higher than those in the good prognosis group,and PAB was lower than that in the good prognosis group(P＜0.05).Bivariate correlation Pearson(N)analysis showed that serum CEA,CYFRA21-1,FIB,and D-D levels were negatively correlated with the survival time of NSCLC patients undergoing chemotherapy(P＜0.05),and serum PAB level was positively correlated with the survival time of NSCLC patients undergoing chemotherapy(P＜0.05).The results of binary Logistic regression analysis showed that the high expression of serum CEA,CYFRA21-1,FIB,and D-D was a risk factor for poor prognosis in patients with NSCLC chemotherapy(OR＞1,P＜0.05),and the high expression of serum PAB was a protective factor for poor prognosis in patients with NSCLC chemotherapy(OR＜1,P＜0.05).The results of ROC curve showed that the AUC of serum CEA,CYFRA21-1,FIB,D-D,and PAB levels in predicting the prognosis of NSCLC patients with chemotherapy AUC was＞0.70,which had a certain predictive value.The levels of serum CEA,CYFRA21-1,FIB,and D-D in patients with NSCLC chemotherapy were positively correlated with the poor prognosis of patients with NSCLC chemotherapy.Especially when serum CEA＞24.53 μg/ml,CYFRA21-1＞7.82 µg/ml,FIB＞3.99g/L,D-D＞1.05 µg/ml,the risk of poor prognosis in patients with NSCLC chemotherapy increased with the increase of serum CEA,CYFRA21-1,FIB,and D-D levels.The level of PAB in patients with NSCLC chemotherapy was negatively correlated with the poor prognosis of patients with NSCLC chemotherapy.When serum PAB＜209.76 g/L,the risk of poor prognosis in patients with NSCLC chemotherapy increased with the decrease in PAB level.Conclusion The levels of serum CEA,CYFRA21-1,FIB,D-D,and PAB are closely related to the prognosis of patients with NSCLC chemotherapy.The above indicators can effectively predict the risk of poor prognosis in patients with NSCLC chemotherapy.
Carcinoma,non-small-cell lungAntineoplastic combined chemotherapy protocolsCarcinoem-bryonic antigenSoluble fragment of cytokeratin 19FibrinogenD-dimerPrealbumin
万方数据
维普
