Correlation analysis of serum interleukin-35 expression level and prognosis of prostate cancer after total androgen deprivation therapy
Objective To investigate the correlation between the expression level of serum interleukin(IL)-35 and the prognosis of prostate cancer patients with total androgen blockade(MAB).Methods Sixty prostate cancer patients who received MAB treatment in our hospital from April 2017 to April 2020 were collected as research objects.The serum IL-35 level of patients before treatment was measured.According to the follow-up results,the receiver operating characteristic curve(ROC)was used to determine the optimal cut-off value of IL-35,and then the participants were divided into low IL-35 group and high IL-35 group.The pathological characteristics of the two groups were compared,and the Kaplan-Meier survival curve and Cox regression model were used to analyze the correlation between serum IL-35 and the prognosis of patients.Results The ROC curve was drawn with a 3-year follow-up as the outcome,and the best cut-off value of IL-35 was 147.73 pg/ml[area under the curve(95％CI)0.667(0.517,0.818,P＜0.001],and this was taken as the critical point to divide the patents into low IL-35 group(＜147.73 pg/ml)and high IL-35 group(≥ 147.73pg/ml).In the high IL-35 group,the proportions of Gleason score＞7 points(58％vs 29％),T4 stage(74％vs 44％)and lymph node metastasis(68％vs 39％)in T stage were significantly higher than those in the low IL-35 group(P＜0.05).The Kaplan-Meier survival curve showed that the progression-free survival(PFS)[(32±4)months vs(23±4)months]and overall survival[(32±3)months vs(24±4)months]of patients in the low IL-35 group were significantly bet-ter than those in the high IL-35 group(P＜0.05).Univariate and multivariate Cox regression model analysis showed that serum IL-35 level[HR(95％CI)=1.044(1.017,1.073)]、[HR(95％CI)=1.035(1.006,1.064)];Gleason score[HR(95％CI)=2.218(1.449,6.307)]、[HR(95％CI)=3.056(1.649,9.447)];clinical T stage[HR(95％CI)=2.056(1.553,5.984)]、[HR(95％CI)=1.900(1.237,11.622]and lymph node metastasis[HR(95％CI)=2.415(2.084,7.445)]、[HR(95％CI)=4.147(1.081,15.910]were independent risk factors for PFS and overall survival in prostate cancer patients treated with MAB(P＜0.05).Conclusion The abnormally elevated serum IL-35 level before treatment is an independent risk factor affecting the prognosis of patients with prostate cancer treated with MAB.
万方数据
维普
