Effects of low molecular weight heparin calcium combined with meropenem on coagulation function and peripheral blood TLR2 and TLR4 levels in patients with severe pneumonia
Objective To investigate the effect of low molecular weight heparin calcium combined with meropenem on coagulation function and levels of Toll-like receptor(TLR)2 and TLR4 in peripheral blood in severe pneumonia(SP).Methods Ninety-six SP patients diagnosed in our hospital(March 2020 to March 2022)were divided into a study group(48 cases)and a control group(48 cases)by randomized control method.The control group was treated with meropenem,and the study group was treated with low molecular weight heparin calcium combined with meropenem.The clinical efficacy,pulmonary function indexes[forced expiratory volume in the first second(FEV1),forced vital capacity(FVC),FEV1/FVC],coagulation function indexes[thrombin time(TT),activated partial thrombin time(APTT),fibrinogen(FIB)],peripheral blood procalcitonin(PCT)and C-reactive protein(CRP),levels of TLR2 and TLR4,incidence of adverse reactions before and after treatment were compared between the two groups.Results The total effective rate of the study group(96％)was higher than that of the control group(83％)(P＜0.05).The indexes of FEV1,FVC,and FEV1/FVC in the study group were higher than those in the control group after treatment(P＜0.05).After treatment,the time of TT and APTT in the study group was longer than that in the control group,and the level of FIB was lower than that in the control group(P＜0.05).After treatment,the levels of PCT,CRP,TLR2,and TLR4 in the peripheral blood of the study group were lower than those of the control group(P＜0.05).After treatment,the total incidence of adverse reactions in the study group(12％)was not significantly different from that in the control group(8％)(P＞0.05).Conclusion Low molecular weight heparin calcium combined with meropenem in the treatment of SP patients can further improve the clinical efficacy,improve the coagulation function of patients,regulate the inflammatory response of the body,reduce the levels of TLR2 and TLR4 in peripheral blood,and it is safe and worthy of clin-ical reference and promotion.
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