Effect of Shexiang Baoxin pill combined with metoprolol in the treatment of angina pectoris of coronary heart disease on its efficacy,and serum NT-proBNP,Hcy level and ApoB/A1 value
Objective To explore the effect of Shexiang Baoxin pill combined with metoprolol in the treatment of angina pectoris of coronary heart disease,and the serum level of N-terminal pro-brain natriuretic peptide(NT-proBNP)and homocysteine(Hcy)level and apolipoprotein B/apolipoprotein A1(ApoB/A1).Methods Total of eighty-eight patients with angina pectoris of coronary heart disease were randomly classified into the Western medicine group(n=44)and integrated Chinese and Western medicine group(n=44).The Western medicine group was treated with metoprolol,and the integrated Chinese and Western medicine group was additionally treated with the Shexiang Baoxin pill on this basis.The scores of Traditional Chinese Medicine(TCM)syndromes of the two groups were evaluated before treatment and after 1 month of treatment,and the efficacy was evaluated in the two groups.The angina pectoris attack,echocardiographic indicators[left ventricular end-diastolic diameter(LVDD),left ventricular ejection fraction(LVEF)],serum blood lipids levels[total cholesterol(TC),triacylglycerol(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C)]and other serum biochemical indicators[NT-proBNP,Hcy,ApoB/A1 value]were compared between the two groups before treatment and after 1 month of treatment.Results Scores of TCM syndromes after 1 month of treatment in both groups were lower than those before treatment(P＜0.05),and the scores of the integrated Chinese and Western medicine group were significantly decreased compared to the Western medicine group(P＜0.05).The total clinical effective rate was significantly higher in the integrated Chinese and Western medicine group than in the Western medicine group(89％vs 70％,P＜0.05).After 1 month of treatment,the frequency of angina pectoris attack,duration of attack,myocardial oxygen consumption,LVDD and LVEF in the two groups were significantly reduced or shortened or increased compared to those before treatment(P＜0.05),and the levels of serum TG,TC,LDL-L,NT-proBNP and Hcy and ApoB/A1 ratio were significantly decreased compared with those before treatment(P＜0.05)while the HDL-C level was significantly increased compared with that before treatment(P＜0.05),and the changes of the above indicators in the integrated Chinese and Western medicine group were greater than those in Western medicine group(P＜0.05).Conclusion Shexiang Baoxin pill has signif-icant efficacy in the metoprolol treatment of angina pectoris of coronary heart disease.In addition,it can relieve the attack of angina pectoris,effectively lower the levels of serum HDL-C and other blood lipid indexes,increase the expression level of LDL-C,inhibit the levels of serum NT-proBNP and Hey,and effectively improve the prognosis of patients.
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