Correlation analysis between quantitative coronary flow fraction and myocardial perfusion imaging in symptomatic myocardial bridge
Objective To compare and analyze the correlation between the quantitative flow rate(QFR)of coronary artery and myocardial perfusion imaging in patients with symptomatic myocardial bridge(SMB),and explore the clinical significance of QFR in evaluating myocardial ischemia caused by coronary myocardial bridging.Methods A total of 203 patients(97 males and 106 females)with left anterior descending artery(LAD)SMB diagnosed by coronary angiography due to myocardial ischemia symptoms such as chest pain and tightness were enrolled consecutively from September 2020 to June 2023.QFR analysis software was used to quantitatively measure the degree of compression stenosis of the SMB diameter,and they were divided into Noble level 1 group(n=126),Noble level 2 group(n=25),and Noble level 3 group(n=52)according to Noble grading.Quantitative coronary angiography(QCA)was used to analyze the myocardial blood supply and perfusion in the SMB region during the systolic phases(SG-QFR)and diastolic phases(DG-QFR)of the SMB segment.Radionuclide myocardial perfusion imaging was performed during hospitalization.Results The general clinical characteristics of Noble 1,2,and 3 groups showed differences only in the presence of SMB lesions(P＜0.05).The DG-QFR of Noble 1,2,and 3 groups were 0.94±0.06,0.90±0.08,and 0.79±0.10(P=0.023),respectively.The SG-QFR values were 0.89±0.08,0.76±0.09,and 0.71±0.07,respectively(P=0.045).The perfusion defects in the nuclide load test were 18％,20％,and 60％,respectively,with statistically significant differences(P＜0.05).The correlation analysis between nuclide-loaded myocardial nuclide perfusion defect and DG-QFR,SG-QFR showed a negative correlation[r=-0.55,-0.54(P＜0.01)].Conclusion D-QFR can better reflect the impact of SMB on myocardial ischemia under the dynamic influence of myocardial bridge on cardiac contraction,however,it only indicates a moderate negative correlation with positive myocardial perfusion imaging.
Myocardial bridgingCoronary angiographyMyocardial perfusion imagingQuantitative flow ratio
万方数据
维普
