Study on the impact of statin drugs on the degree of neurological deficits and SREBP2 expression in progressive cerebral infarction
Objective To observe the effect of statins on the degree of neurological deficits and the expression of sterol regulatory element-binding proteins(SREBP)2 in progressive cerebral infarction.Methods This article is a prospective study,which included 106 patients with progressive cerebral infarction(PCI)admitted to the Second Affiliated Hospital of Henan University of Science and Technology from January 2021 to June 2023.They were randomly divided into a conventional group(53 cases)and a combination group(53 cases)using a computer randomization method.All patients received conventional drug treatment,while the combination group received atorvastatin combined treatment.The lipid levels,serum inflammatory factors,recovery of brain nerve function,and SREBP2 protein expression levels of the two groups were compared.The Spearman correlation coefficient was used to test the correlation between SREBP2 protein expression and the degree of neurological deficits in the brain.Results Under different treatment regimens,the relative expression levels of total cholesterol,low-density lipoprotein cholesterol,and SREBP2 proteins in the combination group were lower than the conventional group;The high sensitivity C reactive protein,matrix metalloproteinase 9,and lipoprotein phospholipase A2 of the combined group were lower than the conventional group.The neuron-specific enolase(NSE)and S100β of the joint group were lower than the conventional group;The NIHSS score and CSS score of the joint group were lower than the conventional group;The MBI score was higher than the control group(P＜0.05).According to the Spearman correlation coefficient test,the expression of SREBP2 protein is correlated with NSE and S100β,NIHSS score,and CSS score are negatively correlated,and positively correlated with the MBI score.Conclusion The expression of SREBP2 protein is closely related to the degree of neurological impairment in PCI.Atorvastatin can effectively improve blood lipid levels and alleviate inflammatory reactions in PCI patients and has a positive effect on promoting the recovery of neurological function in patients.
Brain infarctionStatinsSterol regulatory element binding proteinNeurologic manifesta-tionsCorelaion of data
万方数据
维普
