Clinical study of Xinsuning capsule combined with amiodarone in the treatment of premature ventricular contractions
Objective To observe the therapeutic effect of Xinsuning capsules combined with amiodarone in treating premature ventricular contractions.Methods According to the random number table method,124 patients with premature ventricular contractions were separated into a control group(62 cases with amiodarone)and a study group(62 cases with Xinsuning capsules combined with amiodarone).Clinical efficacy,traditional Chinese medicine syndrome score,dynamic electrocardiogram results,heart function,nitric oxide,endothelin-1,fibrinolytic factor,and drug-related adverse reactions were compared.Results The total effective rate of the study group was higher than that of the control group(P＜0.05).After treatment,the traditional Chinese medicine syndrome score,number of premature ventricular contractions,ST segment descent time,ST segment depression distance,endothelin-1,plasminogen activator inhibitor-1(PAI-1)in both groups were lower than before treatment(P＜0.05),and these indexes in the study group were lower than those in the control group(P＜0.05).After treatment,the stroke volume(SV),left ventricular ejection fraction(LVEF),nitric oxide,and tissue plasminogen activator(t-PA)of the two groups were higher than before treatment(P＜0.05),and these indexes in the study group were higher than those in the control group(P＜0.05).Drug-related adverse reactions showed no statistically significant difference between the two groups(P＞0.05).Conclusion The combination of Xinsuning capsules and amiodarone can improve the dynamic electrocardiogram results and heart function of patients with premature ventricular contractions,reduce traditional Chinese medicine syndrome scores,regulate nitric oxide,endothelin-1,fibrinolytic factors,increase clinical efficacy,and do not increase drug-related adverse reactions.
万方数据
维普
