Expression of glucocorticoid receptor in breast cancer and its clinical significance
Objective To investigate the expression and clinical significance of glucocorticoid receptor(GR)in breast cancer tissues.Methods Paraffin specimens of 140 female breast cancer patients who underwent surgical treatment at the 960th Hospital of PLA Joint Logistics Support Force from July 2021 to June 2023 were selected.The expression of GR in cancer tissues and paracancer tissues was detected by immunohistochemistry,and its relationship with clinicopathological features and different molecular typing was analyzed by X2 test,Fisher's exact probability method,and Kruskal-Wallis'rank sum test.Results The rate of GR protein positivity in breast cancer tissues washigher than that in paracancer tissues(P＜0.05).The rate of GR positivity was higher in histologic grade Ⅰ than in grades Ⅱ and Ⅲ,and the rate of GR positivity was negatively correlated with histologic grade.The rate of GR positivity was higher in TNM stage Ⅲ than in stages Ⅱ and Ⅰ and the rate of GR positivity was positively correlated with the TNM stage.The positive rate of GR in patients with lymph node metastasis was higher than that in patients without metastasis.The positive rate of GR in patients with tumor diameter＞2cm was higher than that in patients with tumor diameter ≤ 2 cm,and the differences were statistically significant(P＜0.05).The GR positive rate was higher in ER-positive tumors than in ER-negative tumors,and the GR positive rate was higher in HER-2 negative tumors than in HER-2 positive tumors.There were significant differences in GR expression among different molecular phenotypes of breast cancer,with the highest rate of GR positivity in Luminal A,followed by Luminal B and TNBC,and less frequently in Her-2 overexpression phenotype,with statistically significant differences(P＜0.05).There was no significant correlation between patients'age,menstruation,PR and Ki-67 and GR expression(P＞0.05).Conclusion GR is highly expressed in breast cancer tissues and correlates with a variety of clinicopathologic features,suggesting that GR may be a potential prognostic indicator of breast cancer progression and a new target for treatment.
Breast neoplasmsReceptor,glucocorticoidImmunohistochemistryPathology
万方数据
维普
