Analysis of the diagnostic value of CT quantitative measurement for sarcopenia in patients with liver cirrhosis
Objective To analyze the diagnostic value of CT quantitative measurement for sarcopenia in patients with liver cirrhosis.Methods From January 2021 to November 2023,128 patients diagnosed with liver cirrhosis in our hospital(study group)and 128 healthy individuals matched in gender and age(control group)were included in this study.The skeletal muscle area at the third lumbar vertebral plane(SMA-L3),lumbar spine bone density,degree of fat infiltration in the posterior muscle fatty infiltration(MFI),CT fat percentage in the erector spinae muscle(CTFF)were measured,and the skeletal muscle index at the third lumbar vertebral plane(SMI-L3)was calculated.Results There was no statistically significant difference in gender and age between the study group and the control group(P＞0.05).SMI-L3 and bone density were lower than those in the control group(P＜0.05),while posterior vertebral muscle MFI,and erector spinae CTFF were higher than those in the control group(P＜0.05).There was no statistically obvious difference in gender and age among patients with different Child-Pugh grades of liver cirrhosis(P＞0.05),while there were statistically significant differences in SMI-L3,bone density,posterior vertebral muscle group MFI,erector spinae muscle CTFF,and incidence of sarcopenia(P＜0.05).There was no statistically obvious difference in gender,bone density,posterior vertebral muscle group MFI,and erector spinae muscle CTFF between patients with sarcopenia cirrhosis and those without sarcopenia cirrhosis(P＞0.05),SMI-L3 was smaller than that of patients without sarcopenia cirrhosis(P＜0.05),and older than that of patients without sarcopenia cirrhosis(P＜0.05).ROC curve of SMI-L3 in diagnosing sarcopenia in patients with liver cirrhosis:the overall area under the receiver operator characteristic curve(ROC)curve(95％CI)was 0.866(0.804,0.927),the area under the ROC curve of males(95％CI)was 0.957(0.882,1.000),and the area under the ROC curve of female(95％CI)was 0.857(0.766,0.948).According to the four-grid table,the sensitivity and specificity of SMI-L3 in diagnosing sarcopenia in patients with liver cirrhosis were 91.0％,90.2％,91.0％,90.2％,and 0.812,respectively.Conclusion CT quantitative measurement has important value in the diagnosis of sarcopenia in patients with liver cirrhosis.
NETL
NSTL
万方数据
