Clinical study on letrozole tablets combined with ethinylestradiol cyproterone tablets regulating sex hormone level and improving ovulation effect in patients with polycystic ovary syndrome
Objective To evaluate the effect of letrozole tablets(based on Diane-35)on sex hormone regulation and ovulation improvement in patients with polycystic ovary syndrome.Methods Data were collected from patients(80 cases)with polycystic ovary syndrome(January 2020 to December 2022)admitted to Xi'an People's Hospital(The Xi'an Fourth Hospital),and they were divided by random number table method into the control group(40 cases were treated with routine therapy and Diane-35)and the observation group(40 cases were treated with letrozole tablets).Both groups were treated for 3 courses and followed up for 6 months.The clinical efficacy,serum prolactin(PRL),follicle-stimulating hormone(FSH),luteinizing hormone(LH),testosterone,anti-mullerian hormone(AMH),inhibin B(INHB)and serine protease inhibitor(Vaspin)levels,ovulation rate,pregnancy rate,mature follicle,maximum follicle diameter,endometrial thickness,adverse reactions of the two groups was analyzed and compared.Results The total effective rate of the observation group was higher.After treatment,the serum levels of PRL,FSH,LH,testosterone,AMH,INHB,and Vaspin of the two groups decreased,and the observation group was lower.Of the observation group,the endometrial thickness was thicker,the ovulation rate and pregnancy rate were higher,the largest follicle diameter was longer,and the number of mature follicles was more,the differences were statistically significant(P＜0.05).Conclusion Letrozole tablets are helpful to regulate the levels of sex hormones and disease-related factors in polycystic ovary syndrome,improve ovulation function,and increase pregnancy rate,and it is not easy to increase the risk of adverse reactions,with remarkable effect.
万方数据
维普
