Prognostic value of serum CA724,CEA,and GDF-15 in peritoneal metastasis and prognosis of colorectal cancer
Objective To analyze the predictive value of serum CA724,carcinoembryonic antigen(CEA),and growth differentiation factor-15(GDF-15)in peritoneal metastasis and prognosis of colorectal cancer.Methods The clinical data of 200 patients with colorectal cancer from January 2019 to December 2023 were retrospectively analyzed,including 80 patients with peritoneal metastasis and 120 patients without peritoneal metastasis.Serum CA724,CEA,and GDF-15 were detected in all patients,and the ROC curve was plotted to analyze the predictive efficacy of serum CA724,CEA,and GDF-15 levels on peritoneal metastasis.Kaplan-Meier method was used to construct the survival time curve.The Cox proportional risk regression model was used to analyze whether serum CA724,CEA,and GDF-15 were independent risk factors for the prognosis of colorectal cancer.Results The serum levels of CA724,CEA,and GDF-15 in the peritoneal metastasis group were higher than those in the non-peritoneal metastasis group(P＜0.05).ROC curve analysis showed that serum CA724,CEA,and GPF-15 had predictive value for peritoneal metastasis of colorectal cancer,with AUC of 0.626,0.734,and 0.661,sensitivity of 0.48,0.72,and 0.51,and specificity of 0.78,0.85 and 0.66,respectively.According to the Kaplan-Meier survival curve,the overall survival rate of CEA-positive patients was lower than that of negative patients(P＜0.05),and there was no difference in overall survival rate between CA724 and GDF-15 positive patients and negative patients(P＞0.05).Cox proportional risk regression model analysis showed that serum CEA was an independent risk factor for the prognosis of colorectal patients,while CA724 and GDF-15 were not.Conclusion CEA shows considerable ability in predicting peritoneal metastasis and prognosis in patients with colorectal cancer.CA724 and GDF-15 are not good indicators for predicting peritoneal metastasis and prognosis,and CEA should be included in the construction of a prediction system for peritoneal metastasis and prognosis of colorectal cancer.
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