Inflammation-related markers play an important role in predicting the severity of first diagnosis of colon cancer
Objective To investigate the predictive effect of inflammation-related markers on the severity of colon cancer in the first diagnosis.Methods Patients with colorectal cancer admitted to the Colorectal Center of Shanxi Provincial People's Hospital from January 29,2020 to December 13,2020.A total of 212 patients were collected.Study the relationship between inflammation-related markers of peripheral blood monocyte-to-lymphocyte(MLR),neutrophil-to-lymphocyte ratio(NLR),and platelet-to-lymphocyte ratio(PLR)and swelling size,lymph node metastasis,liver metastasis,AJCC phase and relationships with tumor markers carcinoembryonic antigen(CEA),carbohydrate antigen(CA)199,carbohydrate antigen(CA)125 levels.Results ①More than half of the 212 cases of colon cancer were male and older than 60 years old,and the inflammation-related marker of MLR,NLR,and PLR increased significantly in patients with swelling greater than 5cm(P＜0.05).Inflammation-related marker of MLR,NLR,and PLR were elevated in patients with lymph node metastasis(P＜0.05).MLR,NLR,and PLR are significantly higher in the AJCC high group than in the AJCC low group(P＜0.05).②Inflammation-related markers(MLR,NLR,and PLL)are positively related to tumor markers.MLR is positively related to CEA,CA199,and CA125 levels(P＜0.05).The NLR is associated with CEA,CA199,and CA125(P＜0.05).The PLR is also related to CEA,CA199,and CA125(P＜0.05).Conclusion The combination of inflammatory markers MLR,NLR,and PLR in colon cancer patients can be used as tools for newly diagnosed tumor characteristics.
万方数据
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