Correlations between the levels of serum inflammatory factors of IL-1β IL-6 IL-10 and TNF-α in patients with acute cerebral infarction and vascular cognitive impairment
Objective To investigate the correlations between the levels of serum inflammatory factors of IL-1β、IL-6、IL-10 and TNF-α in patients with acute cerebral infarction and vascular cognitive impairment(VCI).Methods A total of 178 patients with acute cerebral infarction admitted in Jincheng people's Hospital from August 2020 to July 2022 were enrolled in our study.The cognitive function of all the patients were evaluated by Montreal Cognitive Assessment(MoCA).According to their MoCA scores and"Chinese guidelines for the diagnosis and treatment of vascular cognitive impairment 2019",the patients were divided into two groups of normal cogni-tive function group(Group NCI,84 cases)and vascular cognitive impairment group(Group VCI,94 cases)which is divided into vascular cognitive impairment no dementia group(Group VCIND,64 cases)and vascular dementia group(Group VaD,30 cases),according to DSM-Ⅴ diagnostic criteria.Their levels of Serum inflammatory factors of IL-1β、IL-6、IL-10 and TNF-α were measured during the acute phase(0～14 d),recovery period(15～30 d)and 6 months after cerebral infarction.Then 6 month after cerebral infarction,all patients were scored by MoCA again,and 17 patients who got a four-point increase from their original scores were assigned to Cognitive Im-proved group and 11 patients who got a four-point decrease from their original scores were assigned to Cognitive Deterioration group.And then the correlations between the levels of IL-1β、IL-6、IL-10 and TNF-α of each group and their cognitive functions were compared and evaluated.Results The total MoCA scores of Group NCI,Group VCIND and Group VaD showed a decreasing trend from acute phase to 6 months after cerebral infarction(P＜0.05).Compared with those of Group NCI,the levels of IL-1 β、IL-6、IL-10 and TNF-α in Group VCI increased significantly during the acute phase and recovery period,and expressed highly in the acute phase.At the end of 6 months after cerebral infarction,the levels of IL-1β and TNF-α returned to normal,the expression of IL-6 still increased significantly(P＜0.05),while the level of IL-10 showed a significant decline(P＜0.01).Compared with those of Group VCIND,The levels of IL-1β and IL-6 of Group VaD were significantly higher than those of Group VCIND during the acute phase,recovery period and 6 months after cerebral infarction(P＜0.05),while the expression of TNF-α only incresed significantly during the acute phase and recovery period(P＜0.05),and returned to normal at the end of 6 months after cerebral infarction.On the contrary,the level of IL-10 remained almost the same during the acute phase and recovery period,but decreased significantly at the end of 6 months after cerebral infarction(P＜0.05).At the same time,the levels of IL-1β,IL-6 and TNF-α in cognitive deterioration group were significantly higher than those in cognitive improvement group(P＜0.05),while the level of IL-10 decreased significantly(P＜0.05).Conclusion The levels of serum inflammatory factors IL-1 β、IL-6、IL-10 and TNF-α in patients with acute cerebral infarction were closely related with the cognitive impairment and played an important role in the process of VCIND turning to VaD.IL-1β、IL-6、IL-10 and TNF-α could be used as biomarkers for early diagnosis and prediction of prognosis of VCI.
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