Effect of levonorgestrel in collaboration with GnRH-α on follicle stimulating hormone and micro inflammatory factors in patients with endometriosis
Objective To observe the effect of levonorgestrel combined with gonadotropin-releasing hormone agonist(GnRH)-α on follicle stimulating hormone and micro inflammatory factors in patients with endometriosis.Methods Eighty-six patients with endometriosis admitted to Xi'an International Medical Center Hospital from October 2020 to October 2023 were selected and randomly divided into a study group and a control group using a random number table method,with 43 cases in each group.The control group was treated with GnRH-α for treatment,the research group used a combination of levonorgestrel to compare the clinical efficacy of the two groups.Results The total effective rate of treatment in the study group was higher than that in the control group,and menstrual flow score,subendometrial resistance index(RI),pulsatility index(PI),as well as vascular endothelial growth factor(VEGF),carbohydrate antigen 125(CA125),follicle stimulating hormone(FSH),estradiol(E2),luteinizing hormone(LH),monocyte chemotactic protein-1(MCP-1),interleukin-6(IL-6),tumor necrosis factor(TNF-α),and Interleukin-1 β(IL-1)β in the study group were lower than those in the control group(P＜0.05).Conclusion Levonorgestrel in collaboration with GnRH-α has a good effect in the treatment of endometriosis,which can effectively regulate the patients'sex hormone levels,inhibit abnormal proliferation of the endometrium,improve uterine hemodynamics and micro inflammatory stimulation,thereby alleviating clinical symptoms and prognosis,and has high practicality.
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