Objective:To investigate the mechanism of acupuncture for treatment of rats with chronic stress-induced depression. Methods:SD male rats were randomly divided into three groups,including the control group,model group and acupuncture treatment group. The model group underwent chronic irritation,neonatal isolation and modeling;while the treatment group underwent modeling and synchronous electro-acupuncture treatment. 21 days later,the relative level of ERK1 and adrenal mass in the hippocampus were observed in each group. Results:Compared with the blank group, the adrenal gland volume was increased in the model group and treatment group,as well as the body weight,with signifi-cant differences(P<0. 05);the protein level of ERK1 was significantly reduced in the model group(P<0. 05),while it was not different from the acupuncture group(P>0. 05). Compared with the model group,the adrenal mass in the acupuncture group was statistically different( P<0 . 05 ),and the relative protein level of ERK1 in the acupuncture group was increased( P<0 . 05 ). Conclusion:Acupuncture for treatment of depression can effectively be improved in the adrenal gland volume,and actively increase the ERK pathway.
NETL
NSTL
维普
万方数据
