The expression and significance of hPTTG1 and survivin in rectal carcinoma tissue
Objective: To detect the expression of hPTTCJ1 ( human pituitary - tumour transforming gene, hPTTG1 ) and survivin in rectal carcinoma, rectal adenoma and para - cancerous tissue, explore their correlation and mechanism with biological behavior of rectal cancer. Methods : Sixty specimen of rectal carcinoma were collected from January 2006 to Decemher 2008 in our hospital, immunohistochemical SP staining method was used to detect the expression of hPTTG1 and survivin in 60 cases of rectal carcinoma, 10 cases of rectal adenoma and 10 cases of para cancerous tissues, and analyzed the relationship and hiological behavior among the speciments. Results : The positive rates of hPTTG1 in rectal carcinoma, rectal adenoma and para - cancerous tissues were 80％ ( 48/60 ), 20％ ( 2/ 10 ) and 0 ( 0/10 ) , respectively , ( P ＜ 0. 01 ). The positive rates of survivin in rectal carcinoma , rectal adenoma and para - cancerous tissue were 90％ ( 54/60 ), 80％ ( 8/10 ) and 20％ ( 2/10 ), respectively ( P ＜ 0. 05 ). The expression of hPTTG1 in rectal carcmoma was significantly correlated with Dukes staging, the degree of differentiation, lymph node metastasis and type of the tumor ( P ＜ 0. 05 ). The expression of survivin was significantly correlated with Dukes staging and lyruph node metastasis in rectal carcinoma ( P ＜ 0. 05 ). The expression of hPTTG1 and survivn in rectal adenocarcmoma was not correlated with gender and age of patients, CEA, tumor locations of rectum. Conclusion: hPTTG1 and survivn may play an important role in development and progression of rectal carcinoma, show a close correlation with rectal carcinoma invasion and metastasis.
NETL
NSTL
万方数据
维普
