摘要
目的：比较盐酸戊乙奎醚和阿托品用于开胸手术术前用药对呼吸和循环功能的影响。方法：80例ASA 分级 I - II 级全麻下行开胸手术患者，随机分成两组，P 组（盐酸戊乙奎醚组）和 A 组（阿托品组），每组40例。每组患者麻醉诱导前分别给予盐酸戊乙奎醚0.01mg/ kg，或阿托品0.01mg/ kg，分别记录插管后切皮前（T1）、单肺通气后30min（T2）、单肺通气后60min（T3）、恢复双肺通气后15min（T4）的气道峰压（Ppeak）、气道平台压（Pplat）、肺顺应性（Compl）、气道压力（Paw）以及各时点血压、心率和血气参数变化。结果：P 组患者在 T2、T3、T4时肺顺应性降低的幅度及气道峰压、气道平台压、气道阻力升高的幅度明显低于 A 组（P ﹤0.05）。P 组在 T2、T3、T4时 SaO2明显高于 A 组（P ﹤0.05）。T2、T3时 A 组心率显著高于 P 组。结论：盐酸戊乙奎醚可以改善患者呼吸功能，血流动力学稳定，作用时间长，比阿托品更适合用于开胸手术术前用药。
Abstract
Objective:To compare the effects of penehyclidine hydrochloride and atropine on respiratory and circu-latory function in patients with thoracic surgery. Methods:Eighty pations with ASAI or II treated with thoracic surgery were randomly divided into two groups(group P and group A)with 40 patients in each groups. Group P received pene-hyclidine hydrochloride(group P 0. 01mg/ kg)group A was administered with atropine(group A 0. 01mg/ kg). Mean artery pressure and heart rate were recorded,the arterial blood samples were taken and Ppeak,Pplat,Compl,Paw were recorded at the time point of before operation(T1 ),30min(T2 ),60min(T3 )after one - lung ventilation,15 min after double lung ventilation(T4 ). Results:The Compl,Ppeak,Pplat,Compl and Paw in group P was significantly lower than in group A at T2 ,T3 ,T4(P ﹤ 0. 05),SaO2 in group P was significantly higher than in group A at T2 ,T3 ,T4(P ﹤0. 05). Heart rate was lower in group P than group A at T2 and T3(P ﹤ 0. 05). Conclusion:Compared with atropine, penehyclidine hydrochloride can effectively improve respiratory fuction,the hemodynamics is more stable and effect is longer,which is more suitable for patients ungergoing thoracic surgery.
NETL
NSTL
维普
万方数据