Advances in breast cancer stem cell-related signaling pathways and biomarkers
The main reason for the high mortality rate of breast cancer patients is the recurrence and metastasis of the cancer due to resistance to chemoradiotherapy.Studies have found that the recurrence and metastasis of breast cancer are related to the existence of breast cancer stem cells.The breast cancer stem cells in the tumor have the abil-ity of self-renewal and differentiation,and are resistant to tradition chemoradiotherapy.Breast cancer stem cell-re-lated signalling pathways and biomarkers may provide a strong basis for targeted breast cancer therapy.Currently,breast cancer stem cells are known to be associated with Wnt/β-catenin,Notch,NRF2,PI3K/AKT/mTOR and Hedgehog/Sonic Hedgehog signalling pathways and have markers such as CD24,CD44,CD49,Calreticulin 3,CD 133,EpCAM,Erbb2/HER-2,CXCR1 These markers and signalling pathways are expected to be used as biomarkers for breast cancer diagnosis,progression and metastatic tendency,but there are still challenges in future research.There-fore,we review the signalling pathways and biomarkers associated with breast cancer stem cells and provide an out-look,with the aim of providing theoretical support for breast cancer therapeutic drug research.
breast cancerbreast cancer stem cellssignaling pathwayscell markerstargeted therapyreview
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维普
