Value of blood calcium,PTHrP and PTH1R for the diagnosis of bone metastasis in NSCLC and the evaluation of radiotherapy efficacy
Objective:To investigate the correlation of serum calcium,serum parathyroid hormone-related protein(PTHrP)and parathyroid hormone receptor 1(PTH1R)levels with bone metastasis in non-small cell lung cancer(NSCLC),and its value in the evaluation of radiotherapy efficacy.Methods:40 NSCLC patients with bone metastasis receiving local radiotherapy and treatment of zoledronic acid were investigated.40 patients with bone and 40 patients of non-bone metastases from NSCLC were selected.Patients with bone metastases received radiotherapy.Compare the levels of calcium,serum PTHrP,and PTH1R between the two groups before treatment.The correlation between the lev-els of three different blood substances,and the number of bone metastatic sites,course of disease in were analyzed in the bone metastasis group.The changes of the blood calcium,the serum PTHrP and PTH1R levels before and after therapy were also tested.Results:The levels of blood calcium,serum PTHrP and PTH1R were higher in bone metasta-sis patients than in non-bone metastasis patients(P＜0.05).Patients with more than 3 bone metastatic sites showed higher PTHrP levels compared with those with≤3 bone metastases(P＜0.05).A positive correlation was demonstra-ted between the course of disease and the PTHrP levels,where the longer course of disease was associated with the higher PTHrP levels(P＜0.01).The blood calcium and serum PTHrP levels were significantly reduced due to the ra-diotherapy(P＜0.001).Conclusion:Blood calcium,PTHrP,and PTH1 R levels can used for the diagnosis of bone metastasis in NSCLC.The levels of blood calcium and serum PTHrP can be used as reference indicators for the e-valuation of radiotherapy efficacy.
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