Glutamine metabolic reprogramming is a very important biological feature in the development of cancer,and is one of the important energy sources for the rapid growth of tumor.Some cancer cells cannot survive in the ab-sence of exogenous glutamine,showing glutamine-addictive characteristics.They rely on the hyperactive glutamine transport system to transport large amounts of glutamine into tumor cells to maintain their energy requirements.alanine-serine-cysteine amino acid transporter-2(ASCT2)is a glutamine transporter with high affinity,which is in-volved in the malignant process of many tumors by regulating amino acid metabolism reprogramming.In this paper,the structure and function of ASCT2 and its mechanism of regulating cancer were reviewed.
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