Research progress on the mechanism of SLFN11 involvement in DNA damage response
Drug resistance has become an urgent problem to be solved in cancer chemotherapy.DNA-damage a-gents(DDA)are important drugs using in cancer chemotherapy,but cancer cells can repair the damage through DNA-damage response(DDR),thereby reducing the killing effect of chemotherapy drugs.Therefore,elucidating the mechanism of DNA-damage response is of great significance for increasing the sensitivity of chemotherapy drugs and reducing the dosage of chemotherapy drugs.Schlafen 11(SLFN11)is a DNA/RNA helicase that can sensitize the killing effect of DNA-damage agents on cancer cells.Previous studies have shown that the expression level of SLFN11 in various cancers is significantly positively correlated with the sensitivity of cancer cell DNA-damage a-gents.Therefore,SLFN11 can be used as a predictive biomarker and target of the therapeutic effect of chemotherapy drugs.This review summarises the structure of SLFN11,the mechanism of action involved in DDR,and the research progress in its application in different cancers,providing new strategies for precise anti-cancer therapy and innovative drug development in clinical treatment.
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