Effects of Danzhi Jiangtang capsule and liraglutide on islet β-cell function,glucolipid metabolism and BMI of patients with obese type 2 diabetes mellitus
Objective:To approach the effects of Danzhi Jiangtang capsule and liraglutide on islet β-cell function,glucolipid metabolism and BMI of patients with obese type 2 diabetes mellitus.Methods:80 cases of patients with obese type 2 diabetes mellitus were randomly divided into control group and treatment group,40 cases in each group.The control group was treated with liraglutide,while the treatment group was treated plus with oral Danzhi Jiangtang capsule on the basis of control group.After 12 weeks of treatment,the changes of fasting blood glucose,2 hour postprandial blood glucose,glycosylated hemoglobin,triacylglycerol,total cholesterol,high density lipoprotein cholesterol,low density lipoprotein cholesterol,islet β-cell function and BMI were compared between two groups before and after treatment.Results:After treatment in two groups,FPG,2hPG,HbA1c,TG,TC,LDL-C,HOMA-IR and BMI of patients were decreased,HDL-C and HOMA-β were increased(P＜0.05).And the clinical efficacy of treatment group was better than that of control group,and the difference was statistically significant(P＜0.05).Conclusion:Danzhi Jiangtang capsule and liraglutide can significantly improve the level of glucolipid metabolism of patients with obese type 2 diabetes mellitus,reduce body-weight and enhance insulin resistance,which can prevent and control the progress of diabetes mellitus effectively
type 2 diabetes mellitusobesityDanzhidi Jiangtang capsuleliraglutideintegrated therapy of traditional Chinese and western medicine
万方数据
维普
