Effects of Quanzhen Yiqi decoction on lung function and inflammatory factors in COPD rats with syndrome of failure of the kidney to recieve qi
Objective:To approach the effects of Quanzhen Yiqi decoction on lung function and inflammatory factors in rats with chronic obstructive pulmonary disease(COPD)and with syndrome of failure of the kidney to recieve qi.Methods:39 male SD rats of SPF grade were randomly divided into blank group(n=9),model group(n=10),aminophylline group(n=10)and Quanzhen Yiqi decoction group(n=10).The model was made by LPS and smoking.The rats in drugs group were given corresponding drugs by gavage,while the rats in blank group and model group were given normal saline by gavage once a day.After 28 days,the general situation of rats was observed.Forced vital capacity,forced expiratory volume and peak expiratory flow rate at 0.1 second,white blood cells in bronchoalveolar lavage fluid and classified quantity,serum interleukin and tumor necrosis factor of rats were measured.Results:Compared with model group,forced vital capacity,forced expiratory volume and peak expiratory flow rate at 0.1 second of rats in aminophylline group and Quanzhen Yiqi decoction group all were increased(P＜0.05);while white blood cells in bronchoalveolar lavage fluid and classified quantity,serum IL-6 and TNF-α levels were decreased(P＜0.05).Compared with aminophylline group,white blood cells in bronchoalveolar lavage fluid and classified quantity,serum IL-6 and TNF-α levels in Quanzhen Yiqi decoction group were decreased(P＜0.05).Conclusion:Quanzhen Yiqi decoction can reduce the level of inflammatory factors in COPD rats,and improve lung function of rats.
chronic obstructive pulmonary diseaseQuanzhen Yiqi decoctionlung functioninflammatory factorsexperimental research
万方数据
维普
