Efficacy observation of Gandouling decoction on hepatolenticular degeneration-caused early renal damage
Objective:To observe the clinical efficacy of Gandouling decoction on hepatolenticular degeneration-caused early renal damage with syndrome of intermingled phlegm and blood stasis.Methods:70 cases of inpatients,who were diagnosed as hepatolenticular degeneration-caused early renal damage by The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine,were selected and randomly divided into two groups,35 cases in each group.Both groups were treated with sodium dimercaptosulphonate conventionally.In addition,the control group was treated plus with Bailing capsules,while the treatment group was treated plus with oral Gandouling decoction;6 days as a course of treatment,in total of 4 courses of treatment.The clinical efficacy of patients was observed in two groups after treatment.The changes of following indexes and the incidence of adverse reactions of patients were compared between two groups before and after treatment,such as 24-hour urinary copper,renal function indexes[creatinine(CREA),blood urea nitrogen(BUN)and cystatin C(CysC)],urinary protein series indexes[urinary retinol-binding protein(URBP),urinary β2-microglobulin(U β2-MG),urinary transferrin(UTRF),urinary immunog lobulinG(UIgG),microalbuminuria(m ALB),urinar y α1-microglobulin(U α1-MG)and urinary N-acetyl-β-D-glucosaminidase(UNAG)],24-hour urinary protein quantification(24 hUPQ),oxidative stress indexes[superoxide dismutase(SOD),malondialde hyde(MDA),glutathione peroxidase(GSH-PX)and catalase(CAT)].Results:After treatment,the total effective rate of treatment group was 91.43％,which was higher than 68.57％of control group(P＜0.05);24-hour urinary copper increased in both groups after treatment(P＜0.05),and the increase of treatment group was greater than that of control group(P＜0.05);the levels of CREA,CysC and BUN of treatment group decreased significantly,and the decrease of treatment group was greater than that of control group(P＜0.05);the values of URBP,Uβ2-MG,UTRF,UIgG,mALB,Uα1-MG,UNAG,24 hUPQ of treatment group decreased,and the decrease of treatment group was greater than that of control group(P＜0.05);the levels of SOD,GSH-PX and CAT of patients increased in both groups significantly,while MDA level decreased in both groups significantly(P＜0.05),and the improvement degree of treatment group was better than that of control group(P＜0.05).Conclusion:Gandouling decoction can effectively improve the symptoms of patients with hepatolenticular degeneration-caused early renal damage with syndrome of intermingled phlegm and blood stasis,promote copper excretion in the body,protect renal function,and improve early renal damage.Its clinical efficacy is better.
hepatolenticular degenerationsyndrome of intermingled phlegm and blood stasisGandouling decoctionearly renal damageintegrated therapy of traditional Chinese and western medicine
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