摘要
目的:分析类风湿关节炎中医征候分布规律及不同证型血沉、C反应蛋白的差异性.方法:纳入500例类风湿关节炎患者的横断面资料,对不同中医证型之间性别、年龄、病程、共患心血管疾病及血沉、C反应蛋白进行统计学分析.结果:①与≤60岁组比较,＞60岁组肝肾亏虚证、气阴两虚证较多,而风湿痹阻证、气血两虚证较少(P＜0.05);②与男性组比较,女性组风湿痹阻证、寒湿痹阻证、气血两虚证较多,而湿热痹阻证、瘀血阻络证较少(P＜0.05);③与病程＞15年组比较,病程≤5年、病程6～15年组痰瘀痹阻证较少,风湿痹阻证较多(P＜0.05);与病程≤5年组比较,病程6～15年组风湿痹阻证较少(P＜0.05);④与不共患心血管疾病组比较,共患心血管疾病组痰瘀痹阻证、肝肾亏虚证较多,风湿痹阻证较少(P＜0.05);⑤与痰瘀痹阻证比较,风湿痹阻证和气血两虚证血沉中位数较低(P＜0.05);与气血两虚证比较,湿热痹阻证、痰瘀痹阻证、气阴两虚证C反应蛋白中位数较高(P＜0.05);与风湿痹阻证相比,湿热痹阻证、痰瘀痹阻证、气阴两虚证C反应蛋白中位数较高(P＜0.05).结论:不同证型类风湿关节炎在性别、年龄、病程、共患心血管疾病及血沉、C反应蛋白方面存在着显著性差异.
Abstract
Objective:To analyze the distribution rule of TCM syndromes of rheumatoid arthritis and differences of erythrocyte sedimentation rate(ESR)and C-reactive protein of different syndromes.Methods:The cross-sectional data of 500 patients with rheumatoid arthritis were included.The correlativity between different TCM syndrome types of rheumatoid arthritis and age,gender,course of disease,comorbidity of cardiovascular disease,erythrocyte sedimentation rate and C-reactive protein were analyzed statistically.Results:1.Compared with the group of≤60 years old,syndrome of deficiency of liver and kidney and syndrome of deficiency of both qi and yin were more in the group of＞60 years old,while syndrome of wind-dampness obstruction and syndrome of deficiency of both qi and blood were less(P＜0.05).2.Compared with male group,syndrome of wind-dampness obstruction,syndrome of cold-dampness obstruction and syndrome of deficiency of both qi and blood were more in female group,while syndrome of damp-heat obstruction and syndrome of blood-stasis obstruction in collaterals were less(P＜0.05).3.Compared with the group with disease course＞15 years,for the disease course≤5 years and 6-15 years,syndrome of phlegm-blood stasis obstruction was less,while syndrome of wind-dampness obstruction was more(P＜0.05).Compared with the group with disease course≤5 years,for the disease course for 6-15 years,syndrome of wind-dampness obstruction was less(P＜0.05).4.Compared with the group with non-comorbidity of cardiovascular disease,in the group with comorbidity of cardiovascular disease,syndrome of phlegm-blood stasis obstruction and syndrome of deficiency of liver and kidney were more,while syndrome of wind-dampness obstruction was less(P＜0.05);5.Compared with syndrome of phlegm-blood stasis obstruction,the median of erythrocyte sedimentation rate of syndrome of wind-dampness obstruction and syndrome of deficiency of both qi and blood was lower(P＜0.05).Compared with syndrome of deficiency of both qi and blood,the median of C-reactive protein of syndrome of damp-heat obstruction,syndrome of phlegm-blood stasis obstruction and syndrome of deficiency of both qi and yin was higher(P＜0.05).Compared with syndrome of wind-dampness obstruction,the median of C-reactive protein of syndrome of damp-heat obstruction,syndrome of phlegm-blood stasis obstruction and syndrome of deficiency of both qi and yin was higher(P＜0.05).Conclusion:There are significant differences between different TCM syndrome types of rheumatoid arthritis and gender,age,course of disease,comorbidity of cardiovascular disease,erythrocyte sedimentation rate and C-reactive protein.
基金项目
安徽省阜阳市重点临床科研项目(FYZDYF2023LCYX031)
安徽中医药大学临床科研项目(2023LCTH13)
维普
万方数据