Effect of receptor-tyrosine kinase inhibitor on TCM syndrome elements evolution of advanced lung adenocarcinoma due to epidermal growth factor receptor mutation
Objective:To observe the characteristics of TCM syndrome elements of advanced lung adenocarcinoma due to mutation of epidermal growth factor receptor(EGFR)and the effect of receptor-tyrosine kinase inhibitors(TKIs)on evolution of TCM syndrome elements.Methods:76 cases of patients with advanced lung adenocarcinoma with EGFR mutation were selected.The medical records and four diagnostic methods'informations of patients were collected before the treatment with TKIs as well as in 1 month,3 months,6 months and 12 months after the treatment with TKIs.According to the simplified measurement method in Syndrome Element Syndrome Differentiation,the syndrome elements of patients were statistically analyzed.Results:Before treatment with TKIs,the syndrome elements of disease location were dominated by lung and spleen,while the syndrome elements of lesion nature were dominated by deficiency of qi,phlegm,dampness,fluid-retention and heat commonly.After treatment with TKIs,the frequency of syndrome elements of lung,deficiency of qi,deficiency of blood,phlegm,dampness and fluid-retention was decreased gradually,and the frequency of 3 syndrome elements i.e.lung,deficiency of qi and phlegm was statistically significant in 12 months after treatment compared with before treatment(P＜0.05).The frequency of syndrome elements of spleen,kidney,intestine,skin,deficiency of yin,deficiency of yang,blood stasis and heat was increased gradually with the extension of treatment time.The frequency of syndrome element of deficiency of yin was statistically significant in 6 months after treatment compared with before treatment(P＜0.05).The frequency of 4 syndrome elements of skin,deficiency of yin,deficiency of yang and blood stasis was statistically significant in 12 months after treatment compared with before treatment(P＜0.05).Conclusion:After the patients with advanced lung adenocarcinoma are treated with TKIs,the syndromes of deficiency of lung-qi and phlegm-damp retention are alleviated,while the syndromes of deficiency of yin with interior heat as well as deficiency of yang with blood stasis are aggravated.The auxiliary treatment of traditional Chinese medicine should be based on nourishing yin and clearing heat,strengthening yang and removing blood stasis,which should be applied by syndrome differentiation.
lung cancerreceptor-tyrosine kinase inhibitorepidermal growth factor receptorTCMsyndrome elements
万方数据
维普
