Visual Analysis of Keap1-Nrf2-ARE Signaling Pathway Based on Citespace
Objective To understand the development trends,hotspots,and frontiers of Keap1-Nrf2-ARE signaling pathway research in China,and provide useful references for future research.Methods Retrieve relevant literature on the"Keap1-Nrf2-ARE/ARE"signaling pathway from the China National Knowledge Infrastructure(CNKI)journal service plat-form and Wanfang data knowledge service platform from March 2006 to April 2024.Use visualization software Citespace 6.3 R1(basic version)combined with Excel to extract data and perform visualization analysis.Study the publication trend of Keap1-Nrf2-ARE signaling pathway based on annual publication volume;Perform co-occurrence analysis,clustering analy-sis,timeline analysis,and keyword burst analysis using keywords as nodes;Conduct collaborative network analysis based on the authors and institutions of the literature as nodes.Results A total of 1040 articles were included,and the annual publication volume showed a period of sustained growth and development in the Keap1-Nrf2-ARE signaling pathway field in China;Keyword analysis focuses on the role of the Keap1-Nrf2-ARE signaling pathway in tumors and its relationship with cellular autophagy and inflammatory response.In the future,the Keap1-Nrf2-ARE signaling pathway may serve as a poten-tial target for the prevention and treatment of oxidative stress-related diseases.Author analysis shows that the core authors include Wang Fang,Liu Jian,Wan Lei,etc.,forming a relatively stable collaborative team among different authors;Insti-tutional analysis shows that pharmaceutical universities are the main publishing institutions,and network analysis of institu-tional cooperation reveals that the degree of cooperation between research institutions is not high.In the future,the cooper-ation between research institutions can be strengthened.Conclusion The Keap1-Nrf2-ARE signaling pathway in China has attracted the attention of relevant researchers,and the future research trend is to focus on regulating the Keap1-Nrf2-ARE signaling pathway and applying it to oxidative stress-related diseases.
万方数据
维普
