补阳还五汤加减预防MIS-TLIF术后下肢静脉血栓临床研究
Clinical Study on the Prevention of Lower Limb Venous Thrombosis after MIS-TLIF Surgery with Modified Buyang Huanwu Decoction
董洪伟 1路遥 1卢水生 1王克荣 1吴小辉1
作者信息
- 1. 江西省景德镇市中医医院,江西景德镇 333000
- 折叠
摘要
目的 探究补阳还五汤加减预防微创经椎间孔入路腰椎椎间融合手术(MIS-TLIF)术后下肢静脉血栓的效果.方法 病例选取符合纳入标准及排除标准的景德镇市中医医院骨伤科2021年12月-2023年11月间行MIS-TLIF手术患者60例,根据数字随机分组法分成治疗组、对照组,分别为30例.治疗组运用补阳还五汤加减结合那屈肝素钙口服进行预防;对照组通过那屈肝素钙进行预防;通过观察术后13 d、21 d日本骨科协会腰痛评分表(JOA评分)、D-2聚体、活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)结果.评价补阳还五汤加减的临床疗效.结果 两组患者术后13 dAPTT、PT、D-2聚体、JOA评分差异无统计学意义(P＞0.05).两组患者术后21 dA-PTT、PT、D-2聚体、JOA评分差异有统计学意义(P＜0.05),治疗组APTT、PT、JOA评分大于对照组,治疗组D-2聚体小于对照组.结论 补阳还五汤加减通过改变机体抗凝机制,抑制血小板聚集,从而起到预防下肢静脉血栓的作用,同时恢复腰椎功能.
Abstract
Objective To explore the effect of modified Buyang Huanwu decoction on preventing lower limb venous thrombosis after minimally invasive transforaminal lumbar interbody fusion surgery(MIS-TLIF).Methods Sixty patients who underwent MIS-TLIF surgery in the Orthopedics Department of Jingdezhen Chinese Medicine Hospital from December 2021 to November 2023 and met the inclusion and exclusion criteria were selected as cases.They were randomly divided in-to an observation group and a control group,with 30 patients in each group.The observation group used modified Buyang Huanwu decoction combined with oral administration of nadroparin calcium for prevention;The control group was prevented with nadroparin calcium;By observing the results of the Japanese Orthopaedic Association Low Back Pain Scale(JOA score),D-2 polymer,Activated Partial Thromboplastin Time(APTT),and Prothrombin Time(PT)at 13 and 21 days af-ter surgery.Evaluate the clinical efficacy of modified Buyang Huanwu decoction.Results There was no statistically signifi-cant difference in postoperative 13 day PTT,PT,D-2 polymer,and JOA scores between the two groups of patients(P＞0.05).There was a statistically significant difference(P＜0.05)in postoperative 21 day APTT,PT,D-2 polymer,and JOA scores between the two groups of patients.The observation group had higher APTT,PT,and JOA scores than the con-trol group,while the observation group had lower D-2 polymer scores than the control group.Conclusion The modified Buy-ang Huanwu decoction can prevent lower limb venous thrombosis and restore lumbar spine function by altering the body's anticoagulant mechanism and inhibiting platelet aggregation.
关键词
补阳还五汤加减/经椎间孔腰椎融合术/微创/下肢静脉血栓/预防Key words
Modified Buyang Huanwu decoction/Intervertebral foramen lumbar fusion surgery/Minimally invasive/Lower limb venous thrombosis/Prevention引用本文复制引用
出版年
2025
国家科技期刊平台
NSTL
维普
万方数据