SNP Genotyping Technologies and its Application in Genetic Monitoring in Rats
李欢 1岳秉飞1
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作者信息
1. 中国食品药品检定研究院实验动物资源研究所 国家啮齿类实验动物资源库,北京 102629
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摘要
单核苷酸多态性(SNP)是第三代分子遗传标记,由于其广泛性、遗传稳定性、二态性及易于自动化分型的特点,成为当前实验动物遗传检测领域中重要研究的遗传标记.本文概述了 SNP 概念及特点,重点阐述不同种类SNP 分型技术,并对该技术在大鼠遗传检测研究中的应用进行回顾和展望.
Abstract
Single nucleotide polymorphism(SNP)is the third generation of molecular genetic markers.Due to its universality,genetic stability,dimorphism and easy automatic typing,SNP has become an important genetic marker in the field of experimental animal genetic detection.Therefore,this paper briefly summarizes the characteristics and types of SNP,and focuses on several SNP typing techniques and the application of SNP in genetic detection in rats.
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