子痫前期啮齿类动物模型及其病理改变研究进展
Advances in Rodent Models of Preeclampsia and its Pathological Changes
徐璟 1王秀2
作者信息
- 1. 陕西中医药大学 第二临床医学院,咸阳 712046
- 2. 西安市人民医院(西安市第四医院),西安 710004
- 折叠
摘要
子痫前期是导致孕产妇死亡的第二大原因,对子痫前期的基础病因研究一直是研究的热点.关于子痫前期的体内研究,主要在于如何建模能够全面了解该病的发生发展过程以及对胎仔的影响,国内外研究者通常采用动物建模的方式进行研究,建模方法一般包括生物造模、手术造模、物理造模等,但单一的造模方法仍无法完全复制出与人类相同的模型,还需根据研究方向及预期结果,选择较合适的造模方法.
Abstract
Preeclampsia is the second leading cause of maternal mortality,pathophysiological research on the etiology of preeclampsia has long been a hot topic.About the in vivo research in the pre-eclampsia,mainly lies in how to build a animal model,appropriated animal model can be helpful for fully understanding the occurrence and development of the disease and its impact on the fetal litter,domestic and foreign researchers usually use animal models to study,modeling methods generally include biological modeling,surgical modeling,physical modeling,etc.,but a single modeling method still can not completely produce the same animal preeclampsia model as humans,but also need to choose a more appropriate modeling method according to the research purpose and expected results.
关键词
子痫前期/动物造模/病理改变Key words
preeclampsia/animal modeling/pathological changes引用本文复制引用
基金项目
西安市科技计划(第五批)(2016052SF/YX08)
出版年
2024
NETL
NSTL
维普
万方数据