Effects of Cinnamon Cortex on Endogenous Metabolism in SD Rats
Objective To investigate the effects of cinnamon cortex on the metabolomics of SD rats using 1 H NMR combined with multivariate data analysis,to explore pharmacological mechanism of cinnamon cortex.Method Twenty SD rats were randomly divided into cinnamon cortex-treated groups(CC)and the control groups(TCG).The rats in the cinnamon cortex-treated groups(CC)were intragastric with cinnamon cortex(CC)decoction at the dose of 0.5 g/kg,while the rats in the control groups were intragastric with the same dose of distilled water once a day for 22 days.The dose of cinnamon cortex was according to the Chinese Pharmacopoeia(5 g/person/day).It was determined that urine and fecal samples were collected on day 0,day 5,10 and 22 after cinnamon cortex administration.Result Compared with the blank control group,the contents of 8 metabolites and 7 metabolites were significantly up-regulated in the NMR map of urine samples of the cinnamon cortex administration group on the 22 day.The levels of cadaverine,carnitine,succinate,citric acid and hippuric acid were up-regulated,while the levels of dimethylamine,creatinine,phenylalanine and glycine were down-regulated.In the NMR pattern of fecal samples,the contents of 9 biometabolites were down-regulated and 3 up-regulated,and the levels of adenine and uracil were significantly decreased,while the levels of lactic acid,succinate and acetone were increased,with statistical significance between groups(P<0.01,P<0.05).Conclusion Cinnamon cortex may exert its pharmacological effects by regulating aromatic amino acid metabolism,choline degradation,short-chain fat synthesis and other metabolic pathways.
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